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Application of one group of serum differential protein combination in preparing reagent for detecting Alzheimer's disease

An Alzheimer's disease and differential protein technology, applied in the application field of reagents, can solve problems such as detection delay or misdiagnosis, and achieve the effect of improving objectivity

Active Publication Date: 2019-02-15
SHENZHEN UNIV
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  • Description
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Problems solved by technology

[0004] In view of the deficiencies in the prior art above, the purpose of the present invention is to provide the application of a set of serum protein combinations in the preparation of reagents for detecting Alzheimer's disease, aiming to solve the problem that existing detection methods have certain subjectivity, which is easy to cause Detecting Delayed or Misdiagnosed Issues

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  • Application of one group of serum differential protein combination in preparing reagent for detecting Alzheimer's disease
  • Application of one group of serum differential protein combination in preparing reagent for detecting Alzheimer's disease
  • Application of one group of serum differential protein combination in preparing reagent for detecting Alzheimer's disease

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Embodiment 1

[0034] The present invention uses a combination of computational prediction and experimental verification to identify blood protein markers that can be used for AD diagnosis: first, by comparing and analyzing the transcriptome data of existing Alzheimer's disease patients and normal human brain tissues, Obtain the differentially expressed genes related to Alzheimer's disease; secondly, use the blood protein prediction program to analyze the secretion of proteins encoded by the genes related to Alzheimer's disease into the blood, and obtain the blood proteins related to Alzheimer's disease; then, Through the functional analysis of Alzheimer's disease-related blood proteins, potential Alzheimer's disease blood protein markers were selected; finally, blood samples from Alzheimer's patients and normal people were collected, and enzyme-linked immunosorbent technology (ELISA ) to test these proteins. Therefore, the technical solution of the present invention has higher sensitivity a...

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Abstract

The invention discloses application of one group of serum differential protein combination in preparing a reagent for detecting Alzheimer's disease. The serum differential protein combination is a combination of any three or more than three protein combinations of GSN protein, BDNF protein, TIMP1 protein, VLDLR protein and APLP2 protein. The invention determines the serum differential protein combination which can be used for detecting the Alzheimer's disease. The objectivity, the specificity and the accuracy of the detection can be improved by using the serum differential protein combinationto prepare the reagent for detecting the Alzheimer's disease.

Description

technical field [0001] The invention relates to the technical field of reagent application, in particular to the application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease. Background technique [0002] Alzheimer's Disease (AD), also known as senile dementia, is a neurodegenerative disease, and its incidence rate increases year by year with the increase of population age. Since the pathogenesis of Alzheimer's disease is still unclear and there is a lack of effective treatment drugs, early detection is crucial to curbing or delaying the progression of the disease. The current detection of Alzheimer's disease is mainly based on scales, clinical symptoms, descriptions of patients or family members, clinical experience of clinicians, etc., which has a certain degree of subjectivity and may easily cause delays in diagnosis or misdiagnosis. Therefore, finding fast and effective detection reagents is of great ...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6896
Inventor 姚芳沈立明刘琼
Owner SHENZHEN UNIV
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