Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix

A biomaterial and screening method technology, which is applied in the field of film-like heterogeneous biomaterial transparency screening method and high-transparency acellular dermal matrix, can solve the problems of no screening method, inhomogeneous transparency, and homogeneous acellular dermal matrix In order to achieve the effect of less instruments and experimental materials and easy operation

Active Publication Date: 2021-03-09
PEKING UNIV THIRD HOSPITAL
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the technical solution of the present invention, the current problems of poor homogeneity between different layers of acellular dermal matrix, uneven transparency and no effective screening method can be solved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix
  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix
  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention. The present invention will be described in further detail below through specific implementation examples and in conjunction with the accompanying drawings.

[0038] Such as figure 1 As shown, a method for screening the transparency of a film-like heterogeneous biomaterial, comprising the steps of:

[0039]1) Dehydration of sucrose: Use trephine to drill a circular membranous heterogeneous biological material with a diameter of 6mm, and apply 20% sucrose at 4°C for 24 hours for dehydration. The sucrose treatment...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
elastic modulusaaaaaaaaaa
tensile strengthaaaaaaaaaa
transmittivityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for screening the transparency of a film-shaped heterogeneous biological material, which comprises the steps of dehydration of the biological material sucrose, OCT embedding, layer-by-layer frozen sectioning, and light transmittance measurement with a spectrophotometer. Also provided is a highly transparent decellularized dermal matrix obtained by the above method. Through the present invention, the acellular dermal matrix with the best transparency can be effectively screened out, which can be used for lamellar keratoplasty, and the surgeon can use the above-mentioned matrix to replace the existing lamellar corneal stroma during the operation. At the same time, it can also effectively solve the contradiction of the current shortage of donor corneas.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a method for screening the transparency of membranous heterogeneous biomaterials and a highly transparent acellular dermal matrix. Background technique [0002] The human cornea is a layer of transparent membrane-like structure in front of the human eye. It is an important component of the eye's refractive system, and its function mainly depends on its optical properties. At present, changes in the optical properties of the cornea due to various corneal diseases and injuries have become one of the most important causes of human blindness, ranking second only after cataracts. For irreversible corneal blindness, the most effective and recognized treatment method is allogeneic corneal transplantation. However, there is a serious shortage of corneal donors in my country every year. The lack of sources of corneal materials has become the most important factor limiting the promotio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/31A61L27/36A61L27/50
CPCA61L27/3633A61L27/50A61L2430/16G01N21/31
Inventor 李学民王岳鑫邱伟强刘子源
Owner PEKING UNIV THIRD HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com