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SNP loci for predicting efficacy of high blood pressure individualized drug and detection kit

A detection reagent and kit technology, applied in the field of molecular biology detection

Inactive Publication Date: 2019-02-01
NINGBO AJCORE BIOSCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on the association between polymorphisms on cytochrome P450, especially CYP2C19 and CYP2C19, and the antihypertensive effect of irbesartan

Method used

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  • SNP loci for predicting efficacy of high blood pressure individualized drug and detection kit
  • SNP loci for predicting efficacy of high blood pressure individualized drug and detection kit
  • SNP loci for predicting efficacy of high blood pressure individualized drug and detection kit

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Research object:

[0020] A total of 285 patients with essential hypertension were recruited from three second-class / tertiary-class hospitals in Beijing, including 145 males and 140 females, aged 40-60 years (average age 52.7 years). The research subjects have obvious symptoms of hypertension with systolic blood pressure greater than or equal to 140mm Hg or diastolic blood pressure greater than or equal to 90mm Hg; currently no smoking addiction and alcoholism; according to clinical indications and physical condition, it is suitable to use irbesartan; physical examination has no other symptoms Obvious cardiovascular and cerebrovascular diseases, liver and kidney diseases, blood diseases and metabolic diseases; no other Chinese and Western medicines for lowering blood pressure within two weeks before starting to take irbesartan, and no sartan antihypertensive drugs before entering the group.

[0021] research process:

[0022] 1 Baseline blood pressure measurement and b...

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Abstract

The invention provides SNP loci for predicting the efficacy of a high blood pressure individualized drug and a detection kit. The invention discloses the application of a reagent for detecting the genotype of SNP loci on CYP2C19 and CPY3A5 in preparation of a kit predicating the blood pressure-lowering efficacy of irbesartan, and the SNP loci are 681 G>A (rs4244285) on CYP2C19, 636 G>A (rs4986893)on CYP2C19 and 189-237 G>A (rs776746) on CPY3A5. The invention also provides the corresponding kit and SNP locus combination.

Description

technical field [0001] The application belongs to the field of molecular biology detection and the field of cardiovascular and cerebrovascular diseases. Specifically, the application provides a reagent kit for detecting the genotype of the SNP site on CYP2C19 and CPY3A5 and preparing a kit for predicting the antihypertensive effect of irbesartan The application in , as well as the corresponding kit and SNP site combination. Background technique [0002] Irbesartan, also known as irbesartan or irbesartan, is an angiotensin II receptor antagonist that binds to the angiotensin II type 1 receptor (AT1) with high specificity , reduce blood pressure by causing vasodilation, reducing the secretion of blood pressurizing hormones / factors, reducing aldosterone production and other mechanisms. Irbesartan is a commonly used antihypertensive drug in clinical practice, and its efficacy and tolerability are widely affirmed. However, many clinical practices and related studies have shown ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/106C12Q2600/156
Inventor 周杰锋王德明
Owner NINGBO AJCORE BIOSCIENCES INC
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