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Application of a gold nanoparticle modified by a ferrocene amide molecular compound in pharmacy

A molecular compound and gold nanoparticle technology, which is applied to surface functionalized nanomaterials and their application fields to achieve the effect of diversifying redox catalytic activities

Active Publication Date: 2020-11-17
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, patents and related researches related to the synthesis of gold nanoparticles modified by ferrocenylamide ligand molecular compounds with diverse spatial configurations and π-electron density and their application in the preparation of anti-neurodegenerative disease drugs are still available. No report

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  • Application of a gold nanoparticle modified by a ferrocene amide molecular compound in pharmacy
  • Application of a gold nanoparticle modified by a ferrocene amide molecular compound in pharmacy
  • Application of a gold nanoparticle modified by a ferrocene amide molecular compound in pharmacy

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Example 1 Taking 3,6-dioxoctanediamine and gold nanoparticles (GNP1) modified by benzaldehyde ferrocene derivative molecular compound (Ligand1) as an example to illustrate the modification of ferrocene amide molecular compound described in the present invention Synthesis of gold nanoparticles

[0048] a. Under an ice bath, mix ferrocenecarboxylic acid (11.5 g, 0.05 mol) with 100 mL of dichloromethane (DCM), and stir evenly. Under vigorous stirring, N-hydroxysuccinimide (NHS) (7.0 g, 0.06 mol), 1-(3-dimethylaminopropyl)-3-ethyl carbon Diimine hydrochloride (EDC·HCl) (11.5 g, 0.06 mol). After reacting in an ice bath for 4-6 hours, the solution gradually became clear, and the reaction was monitored by TLC.

[0049] After the reaction was completed, it was suction filtered to obtain a dichloromethane solution of the intermediate.

[0050] b. Under an ice bath, (8.5 g, 0.075 mol) triethylenediamine and 50 mL of dichloromethane (DCM) were mixed and dissolved and stirred ev...

Embodiment 2

[0053] Example 2 Synthesis of gold nanoparticles (GNP2) modified by p-phenylenediamine and benzaldehyde ferrocene derivative molecular compound (Ligand2)

[0054] The preparation method is similar to the preparation of GNP1 in Example 1, the difference is that 32.6mL of 3,6-dioxoctanediamine used in step b is replaced by 27.5mL of p-phenylenediamine, and finally the compound Ligand2 is obtained as a light yellow powder ; The 0.055 g ligand compound Ligand1 used in step d was replaced by 0.056 g ligand compound Ligand2.

[0055] The reaction pathway is shown in formula (IV):

[0056]

Embodiment 3

[0057] Example 3 Synthesis of gold nanoparticles (GNP3) modified by p-phenylenediamine, 4-N, N-dimethylaminobenzaldehyde ferrocene derivative molecular compound (Ligand3)

[0058] The preparation method is similar to the preparation in Example 1, the difference is that the 0.50mL benzaldehyde used in step c is replaced by 0.64mL 4-N,N-dimethylaminobenzaldehyde, and finally the compound Ligand3 is obtained as a light yellow powder ; The 0.055 g ligand compound Ligand1 used in step d was replaced by 0.060 g ligand compound Ligand3.

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Abstract

The invention discloses application of ferrocene amide molecular compound modified gold nanoparticles in the preparation of a medicine against neurodegenerative diseases. The gold nanoparticles are gold nanoparticles modified with 3,6-dioxooctanediamine, benzaldehyde ferrocene-derived molecular compound, or p-phenylenediamine, benzaldehyde ferrocene-derived molecular compound, or p-phenylenediamine, 4-N,N-dimethylaminobenzaldehyde ferrocene-derived molecular compound. The gold nanoparticles can activate GFP-LC3U87 autophagy at different degrees, and the degree of autophagy activation is related to the redox catalytic activity. It is revealed that the gold nanoparticles of the invention are expected to be a potential drug for selectively inducing autophagy and effectively treating Alzheimer's disease.

Description

technical field [0001] The present invention relates to the application of a gold nanoparticle in pharmaceuticals, in particular to the application of a gold nanoparticle modified by a ferrocene amide molecular compound with a variety of spatial configurations and π-electron density in the preparation of anti-neurodegenerative disease drugs The application of the present invention belongs to the field of nano-materials with surface functional modification and their applications. Background technique [0002] With the development of nanotechnology, engineered nanoparticles have a wide range of applications in production, life and nanomedicine. Nanoparticles with diameters smaller than 100 nm have been proposed to be very useful in various medical applications ranging from diagnosis to disease treatment. The tiny size of nanoparticles makes them useful in biomedicine due to their ability to penetrate tissues, including lymph, and be subsequently phagocytized by effector cells...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/242A61K9/16A61K47/54A61P25/28
CPCA61K9/1617A61K33/24A61K47/545A61P25/28
Inventor 闫兵潘秀姣江翠娟王深清孔龙翟淑梅胡春周丽
Owner SHANDONG UNIV
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