Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel application of Danhong blood stasis dispersing composition

A technology of Danhong removing blood stasis and composition, which is applied in the application field of Danhong removing blood stasis composition as a histone deacetylase agonist, and achieves the effects of fast onset time and exact effect.

Inactive Publication Date: 2019-01-29
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no relevant research showing that the application of Danhong Huayu Decoction (DHK) as a SIRT1 agonist can regulate SIRT1 protein

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel application of Danhong blood stasis dispersing composition
  • Novel application of Danhong blood stasis dispersing composition
  • Novel application of Danhong blood stasis dispersing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Research on the role of DHK in regulating SIRT1 / NF-κB signaling pathway

[0029] 1. Experimental animals: SPF grade SD rats; half male and half male; 30 rats in total; 250-280g

[0030] 2. Experimental drugs and instruments:

[0031] Normal saline (Foshan Double Crane Pharmaceutical Co., Ltd.), xylazine injection (Jilin Province Huamu Animal Health Products Co., Ltd.), pentobarbital sodium (Merck, Germany), ceftriaxone sodium for injection (Shenzhen Li Jian Pharmaceutical Co., Ltd.), 2% lidocaine hydrochloride (Hubei Tianyao Pharmaceutical Co., Ltd.), rat CRP ELISA kit (Nanjing Jiancheng Company), rat IL-1β ELISA kit (American eBioscience Company), rat TNF-αELISA Kit (Lianke Biotechnology Co., Ltd.), Rat PAI-1 ELISA Kit (UK Abcam Company), Rat tPA ELISA Kit (UK Abcam Company), BCA Protein Detection Kit (Converse Century Co., Ltd.) , Anti-SIRT1antibody (abcam company), Anti-Akt antibody (CST company), Anti-p-Akt antibody (CST company), Anti-p65antibody (CST ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of a Danhong blood stasis dispersing composition as a silent mating type information regulation 2 homolog 1 (SIRT1) agonist. The Danhong blood stasis dispersing composition comprises seven traditional Chinese medicines of salvia miltiorrhiza, Chinese angelica, ligusticum wallichii, peach kernel, safflower, bupleurum root and bitter orange. As the SIRT1 agonist,the Danhong blood stasis dispersing composition can regulate the expression of SIRT1 protein in blood vessels and play a key role in the prevention and treatment of related diseases. In particular, the Danhong blood stasis dispersing composition has fast onset time and definite effect, and can be used for early prevention of venous embolic diseases.

Description

Technical field: [0001] The invention relates to a new application of Danhong Huayu formula, in particular to the application of Danhong Huayu composition as a histone deacetylase agonist. Background technique: [0002] SIRT1 (silent mating type information regulation 2 homolog 1) is a histone deacetylase dependent on nicotinamide adenine dinucleotide, its physiological role is very complex, related to cell aging, life extension, anti-oxidative stress and energy It is related to various functional activities of cells such as metabolic regulation. The substrates of SIRT1 include histones (K26 of histone H1, K9 of histone H3 and K16 of histone H4) and non-histone proteins (involved in apoptosis, neuron protection, organ metabolic function, cell senescence and tumorigenesis, etc. ) and various transcription factors. SIRT1 protein consists of 500 amino acid residues, and the relative molecular weight of the translated protein is about 60kD. [0003] Danhong Huayu Oral Liquid ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/752A61P9/14A61P7/02A61P29/00
CPCA61K36/232A61K36/233A61K36/236A61K36/286A61K36/537A61K36/736A61K36/752A61P7/02A61P9/14A61P29/00A61K2300/00
Inventor 林娟林宝琴王德勤李楚源张一凡覃仁安
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com