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Ligustrum lucidum glucoside enrichment and its application

A technology of sadaru japonica glycoside enrichment and sadaru japonica glucoside, which can be applied in directions such as pharmaceutical combinations, plant raw materials, and medical preparations containing active ingredients, and can solve the problems of complex formulations of traditional Chinese medicine compositions and the like.

Active Publication Date: 2021-08-20
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN104800564A discloses a complex prescription of traditional Chinese medicine composition

Method used

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  • Ligustrum lucidum glucoside enrichment and its application
  • Ligustrum lucidum glucoside enrichment and its application
  • Ligustrum lucidum glucoside enrichment and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1--the preparation method of Ligustrum lucidum glucoside enrichment

[0022] like figure 1 As shown, 3kg of Ligustrum lucidum plus 12 times the volume concentration of 70% ethanol, reflux extraction for 1.5h, filtered, plus 8 times the volume concentration of 70% ethanol for the dregs, reflux extraction for 1.5h, filtered, Combine the two filtrates, recover the solvent to 3L, add ethyl acetate to extract twice, 3L each time, discard the ethyl acetate layer, add water-saturated n-butanol to extract 3 times, each time 3L, combine the water-saturated n-butanol layer , concentrated, and vacuum-dried to obtain the glucoside enrichment of Ligustrum lucidum, which is used for subsequent test examples.

Embodiment 2

[0023] Embodiment 2--other preparations of Ligustrum lucidum glycoside enrichment

[0024] The values ​​of the three factors of ethanol concentration, volume, and reflux time in Example 1 were adjusted and combined (as shown in Table 1 below), and other preparation methods were kept unchanged to obtain Ligustrum lucidum glycoside enrichment A-H.

[0025] Table 1

[0026]

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PUM

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Abstract

The invention discloses a glycoside enrichment of Ligustrum lucidum, the preparation method of which comprises the following steps: adding 10-14 times of ethanol with a volume concentration of 50-80% to Ligustrum lucidum, refluxing and extracting for 1-3h, filtering, and Add 8 times the amount of ethanol with a volume concentration of 50-80% to the residue, reflux for extraction for 1-3 hours, filter, combine the two filtrates, recover the solvent, add an appropriate amount of ethyl acetate for extraction, discard the ethyl acetate layer, and add water to the water layer to saturate Extract with n-butanol, combine the water-saturated n-butanol layers, concentrate, and vacuum-dry to obtain the glycoside enrichment of Ligustrum lucidum. The invention also discloses the application of the Ligustrum lucidum glucoside enrichment in the preparation of medicine for treating hypoparathyroidism.

Description

technical field [0001] The present invention relates to a glycoside-enriched product of Ligustrum lucidum, and furthermore, the invention also relates to the medical application of the above-mentioned glycoside-enriched product of Ligustrum lucidum. Background technique [0002] Hypoparathyroidism (hypoparathyroidism) is abnormal calcium and phosphorus metabolism caused by decreased secretion and / or dysfunction of parathyroid hormone (PTH). Once it occurs, it will seriously affect the quality of life of patients. Parathyroid injury or missection caused by neck surgery is the most common cause of secondary hypoparathyroidism. The larger the extent of thyroidectomy, the higher the incidence of hypoparathyroidism. When parathyroid hypocalcemia occurs, neuromuscular excitability increases, muscle spasms, tetany and convulsions may occur, and severe cases are life-threatening; bone calcium deficiency is manifested as osteomalacia and loosening; the membrane barrier effect on ion...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/638A61P5/18
CPCA61K36/638A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 张岩王拥军李强刘书芬
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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