Application of brown algae polysaccharide in preparation of pharmaceutical composition for preventing and treating diabetes mellitus

A technology for diabetes drug and fucoidan, which can be applied to drug combinations, metabolic diseases, pharmaceutical formulations, etc., can solve problems such as high cost and inability to cure diabetes, achieve low cost, reduce cost and drug side effects, and inhibit glycogen synthesis.

Inactive Publication Date: 2019-01-25
深圳市慧思基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, drug therapy includes oral drugs, insulin therapy, etc. These drugs are costly and cannot cure diabetes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1 Experiment preparation

[0016] Experimental mice, streptozotocin (Sigma Company), glucose, metformin hydrochloride.

[0017] 2 Establishment of diabetic mouse model

[0018] Streptozotocin was used for intraperitoneal injection of mice, and mice with blood glucose values ​​>12mmol / L were screened as diabetic model mice.

[0019] 3 Preparation of drugs for diabetes treatment and comparison of therapeutic effects

[0020] Take 5g of fucoidan, 2g of schisandra chinensis and 1.75g ​​of salvia miltiorrhiza, pulverize through an 80-mesh sieve, and then bake at 45°C to obtain fucoidan as a therapeutic drug for diabetes; take 30 diabetic model mice and divide them into a blank control group, a fucoidan diabetic drug group, and metformin hydrochloride group, three groups of diabetic model mice were regularly fed with water, algae polysaccharide diabetes treatment drugs, metformin hydrochloride 300mg / kg, fed continuously for 20 days, and then measured fasting blood glucose, ...

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PUM

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Abstract

The invention relates to the technical field of diabetes therapeutic drugs, in particular to the application of brown algae polysaccharide in the preparation of pharmaceutical compositions for preventing and treating diabetes. Compared with the prior art, the invention has the beneficial effects that the medicine for preventing and treating diabetes is prepared by using the brown algae polysaccharide, the schisandra chinensis fruit and the salvia miltiorrhiza root, the medicine can remarkably inhibit glycogen synthesis and glycogen decomposition, and can play a remarkable role in the prevention and treatment of diabetes mellitus; In addition, brown algae polysaccharide and other raw materials have low cost and small side effects, which greatly reduces the cost of treatment and drug side effects.

Description

technical field [0001] The invention relates to the technical field of drugs for treating diabetes, in particular to the application of fucoidan in the preparation of pharmaceutical compositions for preventing and treating diabetes. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Significant genetic heterogeneity exists in both type 1 and type 2 diabetes. Diabetes tends to occur in families, and 1 / 4 to 1 / 2 of patients have a family history of diabetes. Clinically, there are at least 60 genetic syndromes that can be associated with diabetes. Multiple DNA sites are involved in the pathogenesis of type 1 diabetes, among which the polymorphism of the DQ site in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61P3/10A61K31/715
CPCA61K31/715A61K36/537A61K36/57A61K36/79A61P3/10A61K2300/00
Inventor 邱广斌
Owner 深圳市慧思基因科技有限公司
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