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A kind of preparation method and application of nitrofuran antibiotic sensor based on cobalt nickel oxide

A technology of cobalt nickel oxide and nitrofuran, which is applied in chemiluminescence/bioluminescence, analysis by chemical reaction of materials, instruments, etc., can solve the problem of reduced sensitivity, stability and repeatability of electrochemical sensors, Limiting the application of molecularly imprinted membranes and other issues, to achieve the effects of excellent electron transfer ability, convenient operation, and lower detection costs

Active Publication Date: 2021-03-16
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electroanalytical chemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • A kind of preparation method and application of nitrofuran antibiotic sensor based on cobalt nickel oxide
  • A kind of preparation method and application of nitrofuran antibiotic sensor based on cobalt nickel oxide
  • A kind of preparation method and application of nitrofuran antibiotic sensor based on cobalt nickel oxide

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Preparation of CoNiO-nanoarray

[0031] (1) The disposable disposable electrode is ultrasonically cleaned with dilute hydrochloric acid, anhydrous ethanol and deionization to remove the oxide layer and surface impurities of the disposable disposable electrode;

[0032] (2) Weigh 1 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 A mixture of 3 mmol urea CO (NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water, stir until it becomes clear, and then transfer it to a 50 mL polytetrafluoroethylene reactor;

[0033] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at a temperature of 100 ℃ for 12 hours, then take it out and dry it at 300 ℃ annealing for 3 hours to prepare a cobalt-nickel double metal oxide nanosheet array precursor electrode;

[0034] (4) Insert the cobalt-nickel double metal oxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer sol...

Embodiment 2

[0036] Example 2 Preparation of CoNiO-nanoarray

[0037] (1) The disposable disposable electrode is ultrasonically cleaned with dilute hydrochloric acid, anhydrous ethanol and deionization to remove the oxide layer and surface impurities of the disposable disposable electrode;

[0038] (2) Weigh 2 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 A mixture of 6 mmol urea CO (NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water, stir until it becomes clear, and then transfer it to a 50 mL polytetrafluoroethylene reactor;

[0039] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at a temperature of 110 ° C for 11 hours, then take it out and dry it at 350 ° C After annealing for 2 hours, the cobalt-nickel double metal oxide nanosheet array precursor electrode was prepared;

[0040] (4) Insert the cobalt-nickel double metal oxide nanosheet array precursor electrode obtained in step (3) into the phosp...

Embodiment 3

[0042] Example 3 Preparation of CoNiO-nanoarray

[0043] (1) The disposable disposable electrode is ultrasonically cleaned with dilute hydrochloric acid, anhydrous ethanol and deionization to remove the oxide layer and surface impurities of the disposable disposable electrode;

[0044] (2) Weigh 3 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 A mixture of 9 mmol urea CO (NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water, stir until it becomes clear, and then transfer it to a 50 mL polytetrafluoroethylene reactor;

[0045] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at a temperature of 130 °C for 9 hours, then take it out and dry it at 400 °C annealing for 1 hour to prepare a cobalt-nickel double metal oxide nanosheet array precursor electrode;

[0046] (4) Insert the cobalt-nickel double metal oxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer sol...

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Abstract

The invention discloses a fabrication method of a cobalt-nickel oxide-based nitrofuran antibiotics sensor, and belongs to the technical field of novel nanometer functional material and biological sensing analysis. A cobalt-nickel thermometal oxide nanosheet array is fabricated on a disposable throwable electrode, a polydopamine thin film and a molecular imprinting polymer are directly and sequentially fabricated on the cobalt-nickel thermometal oxide nanosheet array by an in-situ growth method according to large specific area, and the molecular imprinting polymer is coated with luminal in an in-situ way and takes nitrofuran antibiotics as a template molecule. After the template molecule is eluted, the original position of the template molecule is changed to holes, and the molecular imprinting molecule of the template molecule is eluted. Therefore, the cobalt-nickel oxide-based nitrofuran antibiotics sensor is fabricated and completed.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemiluminescence sensor. It belongs to the technical field of novel nanometer functional materials and biosensing analysis. Background technique [0002] Nitrofuran antibiotics are a class of 5-nitro-2-substituted furan derivatives, which were once an important class of anti-infective drugs. Such drugs mainly include furazolidone, nitrofurantoin, nitrofurazone, etc., and are mainly used for the treatment of urinary tract infections, intestinal bacterial infections, skin wound infections and as food additives to prevent poultry intestinal infectious diseases. However, in 2005 the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have banned furazolidone for use in humans and animals due to its genotoxic and carcinogenic effects. In addition, nitroheterocyclic compounds have cell mutagenicity and carcinogenic toxicity in animals, which has attracted ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327G01N21/76
CPCG01N21/76G01N27/26G01N27/30G01N27/3278
Inventor 张勇程荣琦魏琴
Owner UNIV OF JINAN
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