Application of long-chain non-coding RNA and compositions thereof in diagnosis/treatment of cholangiocarcinoma

A long-chain non-coding and composition technology is used in the preparation of reagents for diagnosing cholangiocarcinoma, and the long-chain non-coding RNA is used in the preparation and diagnosis of cholangiocarcinoma and the application field of target drug therapy, which can solve the problem of poor prognosis of patients with cholangiocarcinoma. , malignant progression of cholangiocarcinoma

Active Publication Date: 2019-01-22
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are currently clinical treatments such as surgery, radiotherapy, and chemotherapy, the prognosis of patients with cholangiocarcinoma is still poor
Studies have shown that the abnormal expression of lncRNAs mediates the malignant progression of cholangiocarcinoma

Method used

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  • Application of long-chain non-coding RNA and compositions thereof in diagnosis/treatment of cholangiocarcinoma
  • Application of long-chain non-coding RNA and compositions thereof in diagnosis/treatment of cholangiocarcinoma
  • Application of long-chain non-coding RNA and compositions thereof in diagnosis/treatment of cholangiocarcinoma

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Embodiment Construction

[0076] The present invention is further illustrated below with examples, but the present invention is not limited thereto. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed.

[0077] 1. Bioinformatics screening and identification of high expression of ANRIL in cholangiocarcinoma

[0078] (1) The inclusion criteria entered the GEO database ( http: / / www.ncbi.nlm.nih.gov / gds), Query "cholangiocarcinoma" and "cancer of biliary duct", limit the filter conditions "Entry type: Series", "Organism: Homo sapiens", "Study type: Expression profiling by array" and "Attribute name: tissue", get information about cholangiocarcinoma According to the results of microarray research query, select research projects that meet the following requirements: cholangiocarcinoma, case-control (or cancer-adjacent), mainstream microarray platforms (Affy, Agilent, an...

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Abstract

The invention belongs to the field of biological detection, and particularly relates to a reagent and compositions thereof for detecting cholangiocarcinoma and a composition thereof, and application of the reagent and the compositions thereof in preparation of medicaments for cholangiocarcinoma diagnosis and target drug treatment. Meanwhile, the invention also relates to primers of the reagent, and application of the primers in preparation of medicaments for diagnosing colorectal cancer. Study on expression of the long-chain non-coding RNA at the cellular level reveals the relationship of thelong-chain non-coding RNA with the pathogenesis of cholangiocarcinoma.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, ANRIL and its composition, and its application in the preparation and diagnosis of cholangiocarcinoma and target drug treatment. Simultaneously, the present invention also relates to the application of its primers in the preparation of reagents for diagnosing cholangiocarcinoma. By studying the expression of the long non-coding RNA at the cellular level, the relationship between it and the pathogenesis of cholangiocarcinoma was revealed. Background technique [0002] Tumor is a major culprit that seriously threatens human health, and the research on the molecular mechanism of tumor malignant progression has always been the focus and difficulty of the academic circle. It has been reported that tumor cells have cell phenotype characteristics such as promoting proliferation, invasion and metastasis, continuous angiogenesis, immune tolerance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/6886C12N15/11A61K31/7105A61P35/00
CPCA61P35/00A61K31/7105C12N15/113C12Q1/6886C12N2310/14C12Q2600/158C12Q2600/178
Inventor 缪林于洋李全朋王飞张秀华
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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