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Nitrophenol isomer detection array

A technology of nitrophenol and detection array, which is applied in the field of chemical analysis, can solve the problem of not being able to distinguish o-nitrophenol well, and achieve the effect of good discrimination and good dispersion

Active Publication Date: 2019-01-18
BEIJING UNIV OF CHEM TECH
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Problems solved by technology

Obviously, the common disadvantage of these methods is that they cannot distinguish o-nitrophenol and m-nitrophenol well.

Method used

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Embodiment 1

[0024] Synthesis of β-CD and mercaptoundecanoic acid (MUA) bifunctional gold nanoclusters (Au NC1): under stirring, first mix 100 μL NaOH (1M) solution and 24 μL THPC (8%, wt) solution with 8 mL Mix with ultrapure water for 5 min, then add 96 μL HAuCl 4 (Au 3+ , 25mM) solution. Then, 100 μL of β-CD-SH (10 mM) solution was added to obtain β-CD protected gold nanoparticles (β-CD-Au NPs). After stirring at room temperature for an additional 15 minutes, the solution was cooled to 4°C overnight. After aging, 1 mL of β-CD-AuNP stock solution was mixed with 200 µl of sodium carbonate-sodium bicarbonate buffer (0.2 M, pH 9.2) and 75 µl of MUA solution (0.1 M in ethanol) for 2 h to obtain Au NC1 was purified by centrifugation with a 10KDa cut-off ultrafiltration tube for 20min. Store at 4°C until use.

[0025] Synthesis of Au NC2 (β-CD and His bifunctional nanoclusters): HAuCl at room temperature 4 The aqueous solution (1 mL, 10 mM) was mixed with histidine (3 mL, 0.1 M) in a via...

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Abstract

The invention discloses a nitrophenol isomer detection array, which is a beta-cyclodextrin (beta-CD) modification-based dual-ligand functionalized fluorescent Au nanocluster (Au NC) sensor array. A fluorescence quenching mechanism comprises two steps: first, beta-CD adsorbs a nitrophenol isomer to the surfaces of Au NCs under the interaction of a host and a guest; and second, nitrophenol quenchesfluorescence of the Au NCs through an internal filtering effect. Experimental results based on the sensor array show that three isomers can be well distinguished under a concentration of lower than 10[mu]M, and any two mixed isomers can still be well distinguished by the same analysis method. Therefore, the sensor array has substantial application prospect of distinguishing a single isomer from an isomer mixture.

Description

technical field [0001] The invention relates to the technical field of chemical analysis, in particular to a nitrophenol isomer detection array, which is constructed by three kinds of double-ligand functionalized gold nanoclusters for sensing and detecting the nitrophenol isomer. Background technique [0002] Nitrophenol is a compound that is very harmful to human health. Nitrophenol has three isomers, including o-nitrophenol (ONP), m-nitrophenol (MNP) and p-nitrophenol (PNP), and each of them has a different structure, thus showing different toxicity. Many assays for nitrophenols based on fluorescence or UV absorption have been reported. However, the above determination methods are basically aimed at p-nitrophenol. Obviously, the common shortcoming of these methods is that they cannot distinguish o-nitrophenol and m-nitrophenol well. Therefore, it is very important and practical to develop a method to easily distinguish these three isomers. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N21/33
CPCG01N21/33G01N21/643G01N2021/6432
Inventor 袁智勤杨宏伟吕超
Owner BEIJING UNIV OF CHEM TECH
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