A high-throughput tumor-targeted drug concentration screening microfluidic device
A tumor targeting, drug concentration technology, applied in the field of application, can solve the problems of influence, large shear force, destroying cells, etc.
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[0031] DETAILED DESCRIPTION OF THE INVENTION The specific embodiments of the present invention will be further described with reference to the drawings and technical solutions.
[0032] like figure 1 As shown, a high-throughput tumor targeting a drug concentration screening a microfluidic device consisting of a three-layer structure, a cell inlet layer 1 located at the top, a pneumatic film layer 2 located in the middle and a bottom Cellular control layer 3. Among them, the cellular control layer 3 is a key structure of the designed microcataist, has a "two-stage parallel" structure, and the first stage parallel structure is a uniform mixing of particulate tumors to target drugs to generate a variety of proportional drug concentration concentration gradients. Generator module 4, the second stage parallel structure is a multi-cell culture module 5 independently cultured in a variety of cells that can be constructed, uniform, and stable fluid flow microenvironments.
[0033] The con...
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