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Preparation technology for active ingredients of hazel leaves

A technology of active ingredients and hazelnut leaves, which is applied in the field of extraction and purification of active ingredients of fresh hazelnut leaves in traditional Chinese medicine, can solve the problems that there are no technical reports on total tannins extraction, no relevant reports on extraction and separation, etc.

Inactive Publication Date: 2019-01-11
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tannin components in the leaves of this plant have been studied and reported in the literature, and more than ten compounds have been isolated from them, but there is no report on the extraction technology of total tannins with a total content of more than 50%
In particular, there is no relevant report on the extraction and separation of components in fresh hazelnut leaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: Extraction and purification of active ingredient in fresh hazelnut leaves

[0028](1) Take fresh hazelnut leaves, crush them, extract twice with germanium-rich mineral water, soak and extract at room temperature for 3 hours each time, the amount of germanium-rich mineral water is 15 times the total weight of fresh hazelnut leaves, filter, and combine the filtrates to obtain Extraction A; the dregs after extraction are extracted twice with germanium-rich mineral water as a solvent, heated and refluxed for 1 hour each time, the amount of germanium-rich mineral water is 7 times the total weight of fresh hazelnut leaves, filtered, and the combined filtrates are obtained Extraction B; extract the dregs after extraction with 30% ethanol as a solvent, heat and reflux for extraction for 1.5 hours, filter, and combine the filtrates to obtain Extraction E;

[0029] (2) Concentrate the extract A obtained in step (1) under reduced pressure at 35°C to concentrate A wit...

Embodiment 2

[0036] Embodiment 2: Extraction and purification of active ingredient in fresh hazelnut leaves

[0037] (1) Take fresh hazelnut leaves, crush them, extract twice with germanium-rich mineral water, soak and extract at room temperature for 3 hours each time, the amount of germanium-rich mineral water is 15 times the total weight of fresh hazelnut leaves, filter, and combine the filtrates to obtain Extraction A; the dregs after extraction are extracted twice with germanium-rich mineral water as a solvent, heated and refluxed for 1 hour each time, the amount of germanium-rich mineral water is 7 times the total weight of fresh hazelnut leaves, filtered, and the combined filtrates are obtained Extraction B; extract the dregs after extraction with 30% ethanol as a solvent, heat and reflux for extraction for 1.5 hours, filter, and combine the filtrates to obtain Extraction E;

[0038] (2) Concentrate the extract A obtained in step (1) under reduced pressure at 35°C to concentrate A wi...

Embodiment 3

[0042] Example 3: Sugar-free preparation containing fresh hazelnut leaf active ingredient extract and its preparation method

[0043] 2 parts by weight of the active ingredient extract of fresh hazelnut leaves, 230 parts by weight of menthol, 0.3 parts by weight of germanium-rich mineral water; the preparation method is as follows: take the active ingredient extract of fresh hazelnut leaves, isomalt Put ketitol and germanium-rich mineral water in a stirring pot, heat to 105°C, stir for 45 minutes, filter through a 60-mesh sieve, remove moisture under vacuum pressure until the moisture is <1%, cool slightly, add mint according to the ratio of raw materials Brain, after reconciliation, turning and mixing to get the billet evenly, adopt a multi-functional heat preservation stretching machine, uniform the strip, control the temperature of the heat preservation roller bed at 95°C, stretch the strip, the speed of the stretching machine is 800 rpm, stamping and forming, the speed of t...

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Abstract

A technical scheme of the invention discloses an extraction, purification and preparation technology for active ingredients of fresh hazel leaves. According to the technology, fresh hazel leaves are used as a raw material and undergo extraction with germanium-rich mineral water, separation and purification successively so as to obtain the active ingredients of fresh hazel leaves, wherein the active ingredients consist of 1,3-dihydroxy-5,8-dimethoxy-2,4-bis(3-methylbut-2-enyl)-xanthen-9-one, castalagin, Qimurousu and Huagengrousu.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a technology for extracting, purifying and preparing active components of fresh hazelnut leaves, in particular to a technology for extracting and purifying active components of fresh hazelnut leaves in traditional Chinese medicine fresh hazelnut leaves. Background technique [0002] Hazelnut leaves are the leaves of Corylus heterophyllaFi sch. ex Bess., a plant belonging to the Betaceae family. It is widely distributed in Northeast China, North China, Shaanxi, Gansu and other places. The fruit of this product is used for harmonizing, appetizing, improving eyesight, etc. According to records, its leaves contain a large amount of tannins, but there is no detailed report so far. The tannin components in the leaves of the plant have been studied and reported in the literature, and more than ten compounds have been isolated from it, but there is no technical report on the extraction of total ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/22C07D311/86C07D309/10A61K36/185A61K9/16A61K127/00
Inventor 不公告发明人
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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