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A biological preparation for preventing and treating mental disorder based on photosynthetic bacteria and application thereof

A technology for photosynthetic bacteria and mental disorders, applied in the biological field, can solve problems such as metabolic disorders, slow onset of effect, and unfavorable long-term adherence to medication by patients

Active Publication Date: 2019-01-11
UNIV OF SCI & TECH BEIJING +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of drug has obvious defects in the actual application process. First, the onset of effect is slow, and patients need to take the drug for several weeks or even months to take effect; secondly, for a small number of patients, this type of drug has no obvious curative effect; Third, after taking the medicine, there are often various adverse reactions such as gastrointestinal reactions, drowsiness, headache, sexual dysfunction, weight gain, metabolic disorders, etc., which are not conducive to patients' long-term adherence to taking medicine

Method used

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  • A biological preparation for preventing and treating mental disorder based on photosynthetic bacteria and application thereof
  • A biological preparation for preventing and treating mental disorder based on photosynthetic bacteria and application thereof
  • A biological preparation for preventing and treating mental disorder based on photosynthetic bacteria and application thereof

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Experimental program
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Effect test

Embodiment approach

[0047]As mentioned above, the antidepressant and anti-anxiety drugs currently used clinically have obvious defects in the actual application process. First, the onset of effect is slow. For some patients, such drugs have no obvious curative effect; third, there are often various adverse reactions after taking the drugs, such as gastrointestinal reactions, drowsiness, headache, sexual dysfunction, weight gain, metabolic disorders, etc., which are not conducive to long-term adherence of patients take medicine. Therefore, finding a drug that has both preventive and therapeutic effects on the onset of depression and / or anxiety and has low adverse reactions has become a scientific research problem that urgently needs to be overcome. In view of this, the present inventors have conducted a large amount of research on agents for preventing and treating depression and / or anxiety, with the goal of finding probiotics that can prevent and treat depression and / or anxiety through a series o...

Embodiment approach

[0057] According to some embodiments of the present invention, the application includes:

[0058] In step A, the culture of photosynthetic bacteria is separated and processed to harvest photosynthetic bacteria cells;

[0059] Step B, using physiological saline to wash the photosynthetic bacteria cells to obtain pure photosynthetic bacteria cells;

[0060] Step C, diluting the pure product of photosynthetic bacteria cells to make a medicament for preventing and treating mental disorders;

[0061] Wherein, the mental disorders include depression and / or anxiety.

[0062] According to some specific embodiments of the present invention, in step C, the pure product of photosynthetic bacteria cells is diluted with physiological saline to prepare a liquid medicine for preventing and treating mental disorders.

[0063] In some specific embodiments of the present invention, in the liquid medicament for preventing and treating mental disorders, the concentration of photosynthetic bacte...

Embodiment 1

[0084] Experimental animals: The experimental animals used in the present invention are Sprague-Dawley (SD) male rats with an average weight of 200 g, purchased from the Department of Experimental Animal Science, Peking University Health Science Center.

[0085] Test material: the test strain is a typical photosynthetic bacteria strain Rhodopseudomonas palustris (Molisch) van Niel] (CGMCC NO.1.2180). Rhodopseudomonas palustris was cultured anaerobically and heterotrophically under light, the cultures were counted by flow cytometry, and the cells were harvested by centrifugation.

[0086] Test method: Wash the cells with normal saline for 3 times, then dilute them with normal saline to a cell concentration of 10 7 / mL, 10 8 / mL and 10 9 / mL of physiological saline suspension, the rats were subjected to a 28-day intragastric administration experiment of different doses of Rhodopseudomonas palustris, and the intragastric administration amount was 1mL / only / day, and the intragast...

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Abstract

The invention relates to a biological preparation for preventing and treating mental disorder based on photosynthetic bacteria. The preparation belongs to a probiotic agent capable of preventing and treating mental disorders such as depression and / or anxiety disorder, and has both preventive and therapeutic effects on the occurrence of mental disorders such as depression and / or anxiety disorder, and has no adverse reaction. The present invention has developed novel approaches to the prevention and treatment of mental disorders, such as depression and / or anxiety disorders.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a photosynthetic bacteria-based biological preparation for preventing and treating mental disorders and its application. Background technique [0002] Mental disorders are a general term for disturbances in brain functional activities that lead to varying degrees of disorders in cognition, emotion, behavior, and volition, including depression and anxiety. Generally speaking, depression is often accompanied by anxiety symptoms. Depression is mainly depression, and anxiety is often an emotional reflection of patients with depression. With the acceleration of people's work pace and the increasing pressure of life, the incidence of mental disorders continues to rise. The cumulative number of registered patients with severe mental disorders in my country is as high as 4.476 million, and the trend is still increasing. [0003] Depression is a high incidence of mental illness, also known as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61P25/18A61P25/22A61P25/24
CPCA61P25/18A61P25/22A61P25/24A61K35/741
Inventor 闫海李素霞王重阳宋青陆林时杰许倩倩汪庆
Owner UNIV OF SCI & TECH BEIJING
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