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Gradient-degradable porous breast stent

A gradient pore and mammary gland technology, which is applied in the fields of fake breasts, medical science, and prostheses, can solve the problems of deformation, scaffold mechanical stability, and breast tissue regeneration process that cannot be matched, so as to promote rapid growth and good biodegradability , convenient and fixed effect

Active Publication Date: 2019-01-11
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This type of scaffold is prone to irreversible deformation when it lacks autologous tissue as an auxiliary support inside. In other words, the mechanical stability of this type of scaffold cannot match the breast tissue regeneration process

Method used

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Embodiment Construction

[0026] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0027] A degradable gradient pore breast stent, which is composed of a three-dimensional boundary structure and an internal filling structure. The shape of the three-dimensional boundary structure matches the actual tumor contour of the implanted patient, and is obtained by magnifying the actual tumor contour by 1.1 times; the internal The filling structure is a gradient pore structure obtained by three layers of lattice structures with different sizes, and the pores gradually become smaller from the outside to the inside, that is, the unit size of each layer of the lattice structure gradually becomes smaller.

[0028] The actual tumor contour of the implanted patient is obtained by extracting the patient's medical image data, such as figure 1 shown.

[0029] The three-dimensional boundary structure is a reticulated shell structure formed according t...

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Abstract

A gradient-degradable porous breast stent is composed of a three-dimensional boundary structure and an internal filling structure, wherein the shape of the three-dimensional boundary structure is matched with the contour of the actual tumor of the implanted patient; and the internal filling structure is a gradient pore structure obtained by multi-layer lattice structure with different size, and the pore size gradually decreases from outside to inside. The gradient-degradable porous breast stent is prepared by adopting biodegradable material, and after being implanted into the human body, the gradient-degradable porous breast stent can not only repair the breast shape of the patient, but also can match the mechanical stability of the stent and the tissue regeneration process at the initialstage of implantation, and the porous structure is conducive to the growth of tissue cells, easy operation and fixation, cell proliferation and differentiation in the corresponding growth environmentin vivo, stent degradation, autologous tissue growth and infiltration so as to completely replace the implant, to restore the natural breast shape and touch effect.

Description

technical field [0001] The invention relates to the technical field of tissue engineering and biomanufacturing, in particular to a degradable gradient pore mammary gland support. Background technique [0002] Breast reconstruction surgery can alleviate the physical and psychological discomfort of patients after mastectomy, improve the quality of life, and is accepted by more and more patients. Existing breast reconstruction operations include implant reconstruction and autologous tissue reconstruction. The above two breast reconstruction methods have inherent defects. Implantation of non-degradable prostheses such as silicone may cause rejection in the body, leading to complications such as capsular contracture. autologous adipose tissue transplantation also has problems such as lack of blood supply to the implanted tissue, resulting in fat reabsorption and low transplantation efficiency (40%-70% volume loss). [0003] The applicant once proposed an invention patent for a d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/12
CPCA61F2/12A61F2210/0004A61F2250/0023
Inventor 贺健康孟子捷蔡智豪李涤尘仝站国
Owner XI AN JIAOTONG UNIV
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