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Aryl ruthenium complex for treating liver cancer and preparation method and application thereof

A complex, aryl ruthenium technology is applied in the field of aryl ruthenium complex for treating liver cancer and its preparation, and achieves the effects of low cost, good biocompatibility and good biological activity

Inactive Publication Date: 2019-01-04
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors

Method used

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  • Aryl ruthenium complex for treating liver cancer and preparation method and application thereof
  • Aryl ruthenium complex for treating liver cancer and preparation method and application thereof
  • Aryl ruthenium complex for treating liver cancer and preparation method and application thereof

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Experimental program
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Embodiment Construction

[0027] The present invention will be further described in detail below with reference to the embodiments, so that those skilled in the art can implement it according to the text of the description.

[0028] It should be noted that the experimental methods described in the following examples are conventional methods unless otherwise specified, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0029] The chemical name of the aryl ruthenium complex of the present invention is dichloromonochloride (1-(3,4-dihydro-3-isopropyl-2H-pyrimido[2,1-b]benzothiazole) -4-(2-Amino-5-benzylthio-1,3,4-thiadiazole)phenyl)-cymene ruthenium(II);

[0030] Structural formula:

[0031] Physical and chemical properties: red crystals, easily soluble in water and organic solvents, its proton nuclear magnetic resonance spectrum data is 1 H NMR

[0032] (CDCl 3 Solvent): δ7.76 (s, 1H), 7.35 (s, 1H), 7.05-5.66 (m, 13H), 5.39 (d, 1H, J = 5.7 Hz), 5.05 (d, 1H, J =...

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Abstract

The invention discloses an aryl ruthenium complex having the structure as shown in the formula (I), and further provides a preparation method and application of the aryl ruthenium complex. The aryl ruthenium complex has high antineoplastic activity and ACE-inhibiting activity; the preparation method thereof is simple and low in cost, with low loss of raw materials.

Description

Technical field [0001] The invention relates to the field of metal complexes. More specifically, the present invention relates to an aryl ruthenium complex for treating liver cancer and its preparation method and application. Background technique [0002] Malignant tumors have a high fatality rate and are currently one of the most important diseases endangering human health. So far, there is still a lack of effective treatment measures. Most of the anti-tumor drugs in clinical application belong to nucleoside drugs. These drugs have similar anti-tumor spectrum and have strong side effects. On the other hand, some tumor cell lines are prone to drug resistance to clinically applied drugs, and tumor cell lines are also prone to mutation. Therefore, the development of anti-tumor drugs that can overcome drug resistance or have broad-spectrum activities has attracted attention. The anti-tumor spectrum and anti-tumor mechanism of metal complexes are different from those of nucleoside ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61K31/555A61P35/00A61P31/04A61P9/12A61K47/58A61K47/32A61K38/06
CPCC07F15/0046A61K38/06A61K47/32A61K47/58A61P9/12A61P31/04A61P35/00
Inventor 苏炜彭炳华
Owner GUANGXI TEACHERS EDUCATION UNIV
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