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Medicine composition for preventing or treating idiopathic diffuse pulmonary fibrosis

A technology for pulmonary fibrosis and a composition is applied in the field of pharmaceutical compositions for treating idiopathic diffuse pulmonary fibrosis and the field of preparation thereof, which can solve problems such as pulmonary fibrosis that have not yet been seen, achieve no toxic side effects, and enhance lung function , the effect of improving the quality of life

Inactive Publication Date: 2019-01-04
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report of lignans treating pulmonary fibrosis, especially idiopathic diffuse pulmonary fibrosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: A kind of tablet that prevents or treats idiopathic diffuse pulmonary fibrosis

[0030] 5 parts of Mongolian dandelion A, 25 parts of microcrystalline cellulose, 5 parts of 10% starch slurry, 2 parts of sodium carboxymethyl starch, appropriate amount of magnesium stearate, prepared according to the following method:

[0031] (1) material preparation: take each raw material according to the formula;

[0032] (2) Preparation: pass Mongolian dandelion A through a 80-mesh sieve, add microcrystalline cellulose, 10% starch slurry and sodium carboxymethyl starch to make a soft material, pass through a 14-mesh sieve for granulation, and pass through a 12-mesh sieve after drying Granules, add magnesium stearate and mix uniformly and then compress into tablets to obtain the tablet for treating or preventing idiopathic diffuse pulmonary fibrosis of the present invention.

Embodiment 2

[0033] Embodiment 2: A kind of capsule for preventing or treating idiopathic diffuse pulmonary fibrosis

[0034] 5 parts of sageja lignan, 30 parts of microcrystalline cellulose, 5 parts of 10% starch slurry, appropriate amount of magnesium stearate, prepared according to the following method:

[0035] (1) material preparation: take each raw material according to the formula;

[0036] (2) Preparation: pass the sapia lignan through a 80-mesh sieve, add microcrystalline cellulose and 10% starch slurry to make soft materials, pass through a 14-mesh sieve to granulate, pass through a 12-mesh sieve after drying, and add hard After the magnesium fatty acid is mixed evenly, it is filled into the gelatin capsule shell to obtain the capsule of the present invention for treating or preventing idiopathic diffuse pulmonary fibrosis.

Embodiment 3

[0037] Embodiment 3: An aerosol for preventing or treating idiopathic diffuse pulmonary fibrosis

[0038] 5 parts of Mongolian dandelion A, 2 parts of vitamin E, 35 parts of ethanol, appropriate amount of essence, appropriate amount of tetrafluoroethane, prepared according to the following method:

[0039] (1) material preparation: take each raw material according to the formula;

[0040] (2) Preparation: Mongolian dandelion A, ethanol, vitamin E, and essence are mixed, stirred evenly, sub-packaged, and pressed into tetrafluoroethane to obtain the medicine for treating or preventing idiopathic diffuse pulmonary fibrosis of the present invention. aerosol.

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PUM

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Abstract

The invention relates to a medicine composition for preventing or treating idiopathic diffuse pulmonary fibrosis. The medicine composition comprises a lignan compound and a pharmaceutically acceptablecarrier as active ingredients. Preferably, the lignan compound is selected from schisandra chinensis lignan or Mongolian taraxacin A. The medicine composition provided by the invention can be used for the pulmonary fibrosis, particularly the prevention and treatment of the idiopathic diffuse pulmonary fibrosis, and can obviously improve exercise tolerance and pulmonary functions and improve lifequality of a patient.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition for treating idiopathic diffuse pulmonary fibrosis, a preparation method and application thereof. Background technique [0002] Idiopathic diffuse pulmonary fibrosis, a type of pulmonary fibrosis, is a disease of unknown cause characterized by diffuse alveolitis and alveolar structural disturbances leading to pulmonary interstitial fibrosis, which can lead to lung tissue structure Irreversible lesions occur, resulting in the failure of normal gas exchange, with progressive dyspnea as the main symptom, and as the disease progresses, the patient may die due to respiratory failure. At present, glucocorticoids, immunosuppressants, and cytotoxic drugs are mainly used for the treatment of idiopathic diffuse pulmonary fibrosis, but there are problems such as poor therapeutic effect and large side effects. Epidemiological studies have found that the aver...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61K36/288A61P11/00
CPCA61K36/288A61K36/57A61K36/79A61P11/00
Inventor 孔晓霞张宏宇肖健吴疆张海邻
Owner WENZHOU MEDICAL UNIV
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