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Phosphodiesterase 4 inhibitors and application thereof

A phosphodiesterase and inhibitor technology, applied in the field of medicine, can solve problems such as vermilion dilactone that have not been reported

Inactive Publication Date: 2019-01-04
胡艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The prior art has not reported the related reports of vermilion dilactone, isofanthractone, Lushan spices A, bidentate spices, Lushan spices C and phosphodiesterase 4

Method used

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  • Phosphodiesterase 4 inhibitors and application thereof
  • Phosphodiesterase 4 inhibitors and application thereof
  • Phosphodiesterase 4 inhibitors and application thereof

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Experimental program
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Embodiment Construction

[0017] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0018] According to the literature method (Liu Junfeng et al., RP-HPLC determination of phosphodiesterase 4 inhibitory activity of bitter wood alkaloids in vitro, Chinese modern traditional Chinese medicine, 2009 03 issue) determination of vermilion dilactone, isofantrolactone, and Lushan spicein A Inhibition of phosphodiesterase 4 by bidentate spices and Lushan spices C.

[0019] 1. Experimental materials and instruments

[0020] Vermilion Dilactone, Isopredylactone, Lushan Perfume A, Bidentate Perfume and Lushan Perfume C are self-made or purchased, and the purity is not less than 98%. cAMP and the positive drug Rolipram were purchased from Sigma. Lymphocyte separation medium was purchased from Nanjing Jiancheng Biotech. Blood samples were collected from healthy comme...

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Abstract

The invention discloses phosphodiesterase 4 inhibitors and an application thereof, which finds that the labiacinol, isopredomyl lactone, scorpion prostaglandin A and bidentenol are effective phosphodiesterase 4 inhibitors, and the inhibitory effect of scorpion prostaglandin C is not obvious. Among the labiacinol, isopredomyl lactone, scorpion prostaglandin A and bidentenol, the isopredomyl lactonehas the strongest inhibitory effect, which is close to the positive drug rolipram.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the use of known compounds as phosphodiesterase 4 inhibitors, which can be developed into novel anti-inflammatory drugs. Background technique [0002] Phosphodiesterase 4 widely exists in a variety of inflammatory cells and is closely related to a variety of intracellular inflammations. As the only isoenzyme that degrades cyclic AMP, it can be adjusted by adjusting the concentration of phosphodiesterase 4. The concentration level of cyclic AMP in inflammatory cells plays an anti-inflammatory effect. Therefore, phosphodiesterase 4 inhibitors are of great significance for the development of new anti-inflammatory drugs (references: Tang Huifang et al., Research status and future development direction of phosphodiesterase 4 as anti-inflammatory drug target, Journal of China Pharmaceutical University, 2006 Issue 01). [0003] Vermilion dilactone (CAS accession number: 85564-00-7), isofantandrol...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/365A61P29/00
CPCA61K31/366A61K31/365A61P29/00
Inventor 胡艳
Owner 胡艳
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