Use of HIF-2 alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction

Abstract

The present invention provides a use of a HIF-2alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction. The HIF-2alpha inhibitor comprises HIF-2alpha-I2 and / orPT2385; the use according to the invention fully investigates molecular mechanisms and key molecular events and processes of acute high-altitude reaction and hypoxia stress, and a series of experiments shows that HIF-2alpha-I2 and PT2385 both can significantly improve the malignant degree and symptoms including slowing shortness of breath, emotional upset, and high heart rate of acute high-altitude reaction, as well as alleviate the acute hypoxic stress response, so as to achieve the purpose of effectively preventing acute hypoxia. The use has good safety, little side effects and other advantages, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of HIF-2α inhibitors for preparing medicines for preventing and treating acute altitude sickness. Background technique [0002] Hypoxia is a characteristic phenomenon in the special environment of plateau, and it is also the main cause of acute mountain sickness (AMS). Acute altitude sickness (AMS) refers to a series of non-specific clinical manifestations within a few hours after people who have lived in low-altitude areas for a long time have not adapted to the new environment from the plains to areas at an altitude of 3,000 meters and above, including emotional distress. , Insomnia, headache, dizziness, chest tightness, shortness of breath, palpitations, anorexia, nausea, vomiting and a series of symptoms. Most AMS patients usually relieve their symptoms after staying at high altitude for 24-72 hours, and the symptoms gradually disappear after a few days, but a fe...

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Problems solved by technology

However, the above-mentioned prior art has complex components, high cost, cumbersome preparation process, and most importantly, limited clinical curative effect, making it difficult to popularize and apply

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