Molecular imaging probe and application thereof

Abstract

The invention provides a molecular imaging probe which is a polypeptide molecule, including a specific targeted section on one end, a responding assembly-retention section in the middle, and a color developing section on a side chain; wherein the responding assembly-retention section includes a responding sequence as the SEQ ID No.1 and an assembling sequence as the SEQ ID No.2. The molecular imaging probe can recognize a tumor cell through the specific targeted section and achieves assembly retention in a tumor microenvironment through a "responding assembly-retention effect", thereby achieving high-amount and long-acting imaging in a tumor tissue; through near-infrared light excitation, the molecular imaging probe can achieve imaging navigation during a stable and long-acting operation on a tumor focus part, thus achieving visible localization of the tumor. The accuracy of resection of tumors by a doctor is improved, operation success rate is greatly increased and post-operation recurrence rate is reduced; the molecular imaging probe can improve the post-operation life quality of patients.

Description

technical field [0001] The invention relates to the technical field of molecular imaging, in particular to a molecular imaging probe and its application. Background technique [0002] Molecular imaging is a science that uses imaging methods to display specific molecules at the tissue level, cells and subcellular levels, reflects the changes at the molecular level in the living state, and conducts qualitative and quantitative research on its biological behavior in imaging. Therefore, molecular imaging is the product of the combination of molecular biology technology and modern medical imaging, while classic imaging diagnosis (X-ray, CT, MR, ultrasound, etc.) mainly shows the final effect of some molecular changes, with anatomical diseases with anatomical changes; and molecular imaging, through the development of new tools, reagents and methods, to detect abnormalities at the cellular and molecular levels during the disease process, to detect abnormalities before diseases with...

AI Technical Summary

Problems solved by technology

At present, surgical resection of tumor is the main method, and the bladder tissue is removed as a whole, and the quality of life of patients after surgery is severely reduced; partial resection or minimally invasive surgery, some small lesions are difficult to find, and there are situations such as missed cuts and multiple cuts.

The specificity and sensitivity of existing preoperative diagnostic techniques such as B-ultrasound, CT, and MRI need to be improved: for tumors < 8mm, the sensitivity decreases, and it is difficult to image at the molecular level, and can only provide preoperative diagnosis, and cannot achieve surgical diagnosis. real-time imaging navigation

Surgical resection for bladder cancer patients, whether it is open or minimally invasive surgery, depends on the results of preoperative diagnosis. The operation is highly dependent on the doctor's experience, and it is difficult to accurately remove tumor tissue, especially invasive tumors. For small lesions It is even more difficult to find, which leads to a high recurrence rate after surgery.

CN103361403A discloses a kit for detecting bladder cancer-related risk genes. The kit includes a pair of specific primers and a specific fluorescent probe for simultaneously detecting the SNP site rs9642880 on the MYC gene and the SNP site rs2294008 on the PSCA gene. Aiming at conventional components used for fluorescent quantitative PCR detection, the invention assesses the risk of individuals suffering from bladder cancer by simultaneously detecting the genotypes of single nucleotide polymorphisms with MYC and PSCA, but the kit detects Complicated means, unable to achieve tumor localization and imaging

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