Compound for relieving skin wrinkles, preparation method and application thereof

A technology for improving skin and composition, applied in the field of skin care, can solve problems such as uneven quality of repairing cosmetics, large trauma, unsuitable for large-scale treatment, etc., to prevent free radicals from destroying cell structure, strengthen the supply of nutrients, Effect of improving skin growth conditions

Inactive Publication Date: 2018-12-07
友杰医药科技(上海)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The loss of collagen and elastin in the dermis will lead to the decline of skin elasticity and thickness over time, the initial formation of skin fine lines, and gradually lead to skin wrinkles, sagging and folds, which seriously affect the beauty of women
[0003] At present, the common methods of eliminating or lightening fine lines include: (1) Aromatherapy with essential oils. This method has a long course of treatment and has certain technical requirements for the operation of aromatherapy. Obvious effect can be seen; (2) Skin peeling method, skin peeling is carried out by physical or chemical methods. Although this method has quick results, the trauma is relatively large, and sensitive skin is easy to cause new scars, and chemical peeling agents are used etc. are likely to cause adverse reactions; (3) laser therapy, which is not suitable for large-scale treatment, has high technical requirements for laser operation, high cost, and unsatisfactory post-treatment effect; (4) cream massage method, which is passed Using repairing cosmetics combined with massage to promote the absorption of active ingredients and skin repairing is more convenient to operate, has no side effects, and is easily accepted by consumers, but the quality of repairing cosmetics is uneven, and the form is single, and some repairing cosmetics can only play a routine role. Moisturizing and nourishing effect, unable to achieve better repairing effect
[0004] Patent CN107519036 discloses a stretch mark spray containing polypeptide and its preparation method. The preparation contains polypeptide and active growth factor, and the repairing effect is better, but it is in the form of spray, the dosage is large, the form is single, the price is expensive, and the preparation process is difficult. complex
While the use of growth factors to treat aging skin is gaining traction, there remains a significant and unmet need for more effective and diverse topical formulations,

Method used

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  • Compound for relieving skin wrinkles, preparation method and application thereof
  • Compound for relieving skin wrinkles, preparation method and application thereof
  • Compound for relieving skin wrinkles, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment provides a composition for improving skin fine lines, the functional components of the composition are as follows: 1.0% hyaluronic acid; 1.0% trehalose; 2.0% epidermal growth factor; 2.0% centella asiatica extract; L-Ascorbic Acid 2-Glucoside 2.0%; Glutathione 0.5%; Dextran 3.0%; Cross-linked Sodium Hyaluronate 0.1%; Collagenase 0.1%.

[0043] The composition is in the form of a serum.

[0044] The present embodiment also provides the preparation method of this essence for improving fine lines of skin, comprising the following steps:

[0045] (1) Weighing respectively 1.0% hyaluronic acid, 1.0% trehalose, 2.0% epidermal growth factor, 2.0% Centella asiatica extract, 2.0% L-ascorbic acid 2-glucoside, Add 0.5% glutathione, 3.0% dextran, 0.1% cross-linked sodium hyaluronate and 0.1% collagenase, add 7.0% glycerin by weight, stir for 15 minutes, and evenly disperse to obtain mixture A ;

[0046] (2) In the mixture A, add 80.6% water by weight, stir at 50r...

Embodiment 2

[0052] This embodiment provides a composition for improving skin fine lines, the functional components of the composition are as follows: 0.1% hyaluronic acid; 5.0% trehalose; 2.0% epidermal growth factor; 1.0% centella asiatica extract; L-Ascorbic Acid 2-Glucoside 1.0%; Glutathione 0.5%; Dextran 5.0%; Cross-linked Sodium Hyaluronate 1.5%; Collagenase 0.5%.

[0053] The composition is in the form of a serum.

[0054] The present embodiment also provides the preparation method of this essence for improving fine lines of skin, comprising the following steps:

[0055] (1) Weighing respectively 0.1% hyaluronic acid, 5.0% trehalose, 2.0% epidermal growth factor, 1.0% Centella asiatica extract, 1.0% L-ascorbic acid 2-glucoside, Add 0.5% glutathione, 5.0% dextran, 1.5% cross-linked sodium hyaluronate and 0.5% collagenase, add 5.0% glycerin by weight, stir for 18 minutes, and evenly disperse to obtain mixture A ;

[0056] (2) In the mixture A, add 77.7% water by weight, stir at 50r...

Embodiment 3

[0062] This embodiment provides a composition for improving skin fine lines, the functional components of the composition are as follows: 8.0% hyaluronic acid; 15.0% trehalose; 0.1% epidermal growth factor; 5.0% centella asiatica extract; L-Ascorbic Acid 2-Glucoside 1.0%; Glutathione 5.0%; Dextran 10.0%; Cross-linked Sodium Hyaluronate 10.0%; Collagenase 8.0%.

[0063] The composition is in the form of a serum.

[0064] The present embodiment also provides the preparation method of this essence for improving fine lines of skin, comprising the following steps:

[0065] (1) Weighing respectively 8.0% hyaluronic acid, 15.0% trehalose, 0.1% epidermal growth factor, 5.0% Centella asiatica extract, 1.0% L-ascorbic acid 2-glucoside, Add 5.0% glutathione, 10.0% dextran, 10.0% cross-linked sodium hyaluronate and 8.0% collagenase, add 5.0% glycerin by weight, stir for 20 minutes, and evenly disperse to obtain mixture A ;

[0066] (2) In the mixture A, add 32.0% water by weight, stir ...

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Abstract

The invention provides a compound for relieving skin wrinkles. The compound comprises the following components by weight percent: 0.1-8.0% of hyaluronic acid, 1.0-15.0% of mycose, 0.1-8.0% of epidermal growth factor, 1.0-5.0% of centella extract, 1.0-2.0% of L-ascorbic acid 2-glucoside, 0.5-5.0% of glutathione, 3.0-10.0% of glucan, 0.1-10.0% of cross-linking sodium hyaluronate and 0.1-8.0% of collagenase. The collagenase and cross-linking sodium hyaluronate are creatively added into the compound provided by the invention, so that the skin wrinkles can be effectively relieved. The invention also provides a preparation method for products in various forms of emulsion, essence, gel, cream, ointment, tincture, lotion, membrane, paster (containing hydrogel paster), and the like. The preparationmethod is simple in process, is convenient for large-scale production and meets diversified choices of different customers. The compound provided by the invention can be introduced into the skin withthe aid of beauty apparatuses, such as micro-needle, ultrasonic, infrared, electric pulse and low / medium frequency instruments in a use process, and the absorbing effect acquired in such a manner isbetter than that acquired by direct applying.

Description

technical field [0001] The invention belongs to the technical field of skin care, and in particular relates to a composition for improving skin fine lines, a preparation method and an application thereof. Background technique [0002] The loss of collagen and elastin in the dermis will lead to the decline of skin elasticity and thickness over time, the initial formation of skin fine lines, and gradually lead to skin wrinkles, sagging and folds, which seriously affect the beauty of women. [0003] At present, the common methods of eliminating or lightening fine lines include: (1) Aromatherapy with essential oils. This method has a long course of treatment and has certain technical requirements for the operation of aromatherapy. Obvious effect can be seen; (2) Skin peeling method, skin peeling is carried out by physical or chemical methods. Although this method has quick results, the trauma is relatively large, and sensitive skin is easy to cause new scars, and chemical peelin...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/66A61K8/64A61K8/60A61K8/02A61K8/04A61Q19/00
CPCA61K8/735A61K8/0208A61K8/042A61K8/60A61K8/602A61K8/64A61K8/66A61K8/73A61K8/9789A61Q19/00
Inventor 钱峙涛侯巍
Owner 友杰医药科技(上海)有限公司
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