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Composition having lyotropic liquid crystal structure, and preparation method and application thereof

A technology of lyotropic liquid crystals and compositions, applied in the field of physical chemistry, can solve problems such as poor structural stability of lyotropic liquid crystals, phase transition, and narrow stable temperature range of lyotropic liquid crystals

Active Publication Date: 2018-12-04
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the stability of the existing lyotropic liquid crystal structure is not good, and it is easy to undergo phase transition with the change of temperature, and there are often multiple adjacent phase transition temperatures, so that the stable temperature range of the lyotropic liquid crystal is too narrow, which is not conducive to Applications in chemicals and pharmaceuticals

Method used

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  • Composition having lyotropic liquid crystal structure, and preparation method and application thereof
  • Composition having lyotropic liquid crystal structure, and preparation method and application thereof
  • Composition having lyotropic liquid crystal structure, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 Drawing of phase diagram of lecithin / ethyl oleate-1,2-propanediol (1:1) / water ternary system

[0056] Accurately weigh ethyl oleate and 1,2-propanediol at a mass ratio of 1:1 and mix them with a vortex mixer to obtain a homogeneous ethyl oleate-1,2-propanediol substance. Weigh lecithin and oleic acid respectively Ethyl ester-1,2-propanediol homogeneous substance, whose mass ratio varies from 10:0 to 0:10, is added to a colorimetric tube with a stopper, fully stirred and mixed evenly in a water bath at 60-70°C, and poured into the colorimetric tube Add double distilled water dropwise in the middle, the mass percent of double distilled water increases with the interval of 2-4%, and time interval is 15 minutes. After fully stirring and mixing evenly, place the colorimetric tube containing the sample in a constant temperature water bath at 37°C for at least 30 minutes to achieve phase equilibrium. When approaching the phase boundary, the equilibrium time needs t...

Embodiment 2

[0058] The preparation of embodiment 2 compositions

[0059] Select six sample points (i.e. B1, B2, B3, B4, B5, B6, such as figure 1 shown), according to figure 1 As shown, 6 sample points have the composition and content shown in Table 1.

[0060] Weigh lecithin and oil phase (i.e. ethyl oleate-1,2-propanediol (1:1) homogeneous matter respectively according to the composition and content shown in Table 1, which is obtained by adding ethyl oleate and 1,2-propanediol to The mass ratio of 1:1 is obtained by weighing accurately and mixing with a vortex mixer), then put it into the colorimetric tube, fully stir and mix evenly in a water bath at 60-70°C, and add twice distilled water dropwise to the colorimetric tube , the mass percentage of double distilled water is increased at intervals of 2-4%, and the time interval is 15 minutes. Use a centrifuge for about 10 minutes to remove air bubbles, and then equilibrate in a water bath at 25°C for 7 days to allow the liquid crysta...

Embodiment 3

[0063] The measurement of embodiment 3 polarizing texture

[0064] The compositions S1-S6 prepared in Example 2 were made into sheets, and were equilibrated at the temperature shown in Table 2 for 15 minutes using a constant temperature water bath device, and the polarized texture was observed using a BK-POL polarizing microscope, and the relevant digital photos were used The camera of OPTEC TP DV500 connected to the computer is shooting, the result is as follows Figure 2-7 shown.

[0065] The equilibrium temperature of table 2 compositions S1~S6

[0066]

[0067]

[0068] Result analysis:

[0069] Composition S1 is relatively dense texture (such as figure 2 As shown in A), as the temperature increases to about 40°C, the polarized texture tends to be sparse (such as figure 2 B), continue to heat up to about 70°C (higher than 60°C) and appear denser texture (such as figure 2 C), indicating that phase transition occurs with the increase of temperature;

[0070]...

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Abstract

The invention provides a composition having a lyotropic liquid crystal structure, and a preparation method and an application thereof. The composition comprises lecithin, an oil phase and water, wherein the oil phase is a uniform material obtained after uniformly mixing ethyl oleate with 1,2-propylene glycol. The composition has the liquid crystal structure, particularly the stable liquid crystalstructure, and can keep stable and do not change the phase in a wide temperature range, such as in the range of 25-70 DEG C.

Description

technical field [0001] The invention relates to the field of physical chemistry, in particular to a composition with a lyotropic liquid crystal structure and a preparation method and application thereof. Background technique [0002] Surfactant amphiphilic molecules can form ordered aggregates of various structures in water, including micelles, vesicles, microemulsions, lyotropic liquid crystals, etc. Among them, lyotropic liquid crystals have attracted extensive attention due to their diverse structures. Lyotropic liquid crystal (LLC) is a long-range ordered and short-range disordered aggregation structure formed by amphiphilic molecules in a solvent. The common liquid crystal structure types mainly include lamellar phase liquid crystal, hexagonal phase liquid crystal and cubic phase liquid crystal. Lyotropic liquid crystals are used as carriers of various drugs due to their own structural characteristics. The hydrophilic region in lyotropic liquid crystals can dissolve wat...

Claims

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Application Information

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IPC IPC(8): A61K47/24A61K47/14A61K47/10A61K31/12A61P3/06A61P35/00A61P29/00A61P1/16A61P39/06A61K8/55A61K8/37A61K8/34A61K8/02A61Q19/00
CPCA61K8/0295A61K8/345A61K8/37A61K8/553A61K31/12A61K47/10A61K47/14A61K47/24A61K2800/10A61Q19/00A61P1/16A61P3/06A61P29/00A61P35/00A61P39/06
Inventor 李振岳莹王仲妮
Owner SHANDONG NORMAL UNIV
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