Continuous flowing preparation system and method

Abstract

The invention discloses a continuous flowing preparation system and method. The system comprises a controller, and a sample feeding channel, a reactor and a sample discharging channel successively connected. A reaction liquid enters a tubular reactor through the sample feeding channel and a product flows out from the sample discharging channel; the reactor is the tubular reactor which comprises aconductive reaction tube and a power supply module. The power supply module comprises a power supply output end and a control end. The output end of the power supply is electrically connected to two ends of the reaction tube; a temperature sensor is arranged on the reaction tube, the temperature sensor detects a temperature signal in the reactor and transmits the temperature signal to the controller, and the controller controls the output voltage of the power supply module through the control end of the power supply module according to the received temperature signal so as to control the reaction temperature in the reactor. The system and method can overcome the defects that an existing flowing chemical synthetic system is limited in heat transfer rate and is not suitable for large flow continuous flowing preparation, improves the heat transfer efficiency of the reactor and the production efficiency of flowing synthesis, and multiple parameters in the reaction process can be adjusted.

Description

technical field [0001] The invention relates to the technical fields of chemistry, material and chemical industry, especially the continuous flow preparation system and method. Background technique [0002] Flow Chemistry, or Continuous Flow Chemistry, refers to a chemical reaction in which materials are transported by a pump and carried out in a specific channel in a continuous flow mode to achieve continuous flow synthesis. While flow chemistry is a well-established technology in the production of bulk chemicals such as those in the petrochemical industry, it is a relatively new concept that is still in the laboratory stage of development in the synthesis of complex chemicals such as pharmaceuticals. Due to its unique advantages in complex chemical reactions, especially in the preparation of pharmaceutical intermediates, flow synthesis has been favored by international pharmaceutical giants. Large companies such as Merck AG and Sigma-Aldrich began related research at the e...

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Problems solved by technology

[0005] The purpose of the present invention is to propose a continuous flow preparation system and method, which overcomes the defects of the current flow chemical synthesis system that the heat transfer rate is limited and is not suitable for large-flow continuous flow preparation, improves the heat transfer efficiency of the reactor, and improves the efficiency of flow synthesis. production efficiency, and can realize the adjustment of multi-parameters in the reaction process

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