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Pharmaceutical composition for relieving cough and reducing sputum

A technology for relieving cough and reducing phlegm and composition, which is applied in the field of pharmaceutical composition for relieving cough and reducing phlegm and its preparation, which can solve the problem that the therapeutic effect is no longer obvious, and achieve the effect of remarkable efficacy and quick onset

Active Publication Date: 2018-11-27
北京东方运嘉科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the prolongation of the use time, many patients gradually find that the therapeutic effect is no longer obvious, and some drugs need to be replaced for treatment.

Method used

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  • Pharmaceutical composition for relieving cough and reducing sputum
  • Pharmaceutical composition for relieving cough and reducing sputum
  • Pharmaceutical composition for relieving cough and reducing sputum

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] 1.3.2 Preparation of mouse tracheal secretions

[0036] 45 minutes after the last administration, 0.5 ml of phenol red was injected intraperitoneally, and 15 minutes later, the rats were killed by neck dislocation and the trachea was separated. Aspirate 1.5ml NaHCO3, ultrasonically wash, then carefully lavage the inner wall of the trachea with a syringe, and centrifuge at 3000 rpm / 10min to obtain the mouse tracheal secretion.

[0037] 1.3.3 Drawing of standard curve and detection of phenol red excretion

[0038] (1) Configuration of standard products: Dilute phenol red with physiological saline to 0, 10, 20, 40, 80, 120, 160 μg / ml for drawing a standard working curve.

[0039] (2) According to 100μl / well, add the standard substance and the sample to be tested respectively into the 96-well plate according to a certain order.

[0040] (3) Measure the absorbance at 546 nm with a microplate reader.

[0041] (4) Calculate the concentration: calculate the regression equati...

Embodiment 1

[0108] Orange 300g, Scutellaria baicalensis 400g, Golden buckwheat 400g, Baibu 250g, perilla seed 200g, seabuckthorn 200g, aster 200g, bellflower 200g

[0109] Take scutellaria baicalensis, perilla seeds and basil, add 8 times and 6 times the volume of 95% ethanol, reflux extraction twice, each time for 2 hours, filter, combine the filtrates, recover ethanol, concentrate under reduced pressure to a relative density of 1.25 -1.30 thick ointment, dregs for later use; take Huajuhong, seabuckthorn, aster, platycodon, golden buckwheat and the first three medicinal dregs and decoct them with 8 times and 6 times the amount of water respectively, for 2 hours each time, extract The liquid is filtered, concentrated under reduced pressure to a thick paste with a relative density of 1.25-1.30, combined with the above thick paste, and dried under reduced pressure to obtain a dry paste, which is prepared into granules according to conventional methods.

Embodiment 2

[0111] 400g orange red, 450g skullcap, 450g golden buckwheat, 200g basil, 225g perilla seed, 175g seabuckthorn, 250g aster, 150g bellflower

[0112] Take scutellaria baicalensis, perilla seeds and basil, add 8 times the volume of 95% ethanol, reflux extraction twice, each time for 1.5 hours, filter, combine the filtrates, recover ethanol, concentrate under reduced pressure to a relative density of 1.25-1.30 Thick ointment and medicinal dregs for later use; separately take Huajuhong, seabuckthorn, aster, platycodon, golden buckwheat and the first three medicinal dregs, decoct and extract with 8 times the amount of water respectively, each time for 1.5 hours, filter the extract, and decompress Concentrate to a thick paste with a relative density of 1.25-1.30, combine with the above thick paste, and dry under reduced pressure to obtain a dry paste, which is prepared into granules according to a conventional method.

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Abstract

The invention relates to a pharmaceutical composition for relieving cough and reducing sputum and a preparation method thereof. The composition is prepared from tangerine exocarp, fructus perillae, wild buckwheat, scutellaria baicalensis, radix stemonae, sea-buckthorn, radix asteris and platycodon grandiflorum. The pharmaceutical composition has the excellent effect of relieving cough and reducingsputum and can used for treating various diseases causing excessive phlegm. The preparation method is used for preparing the composition.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine, more specifically, to a pharmaceutical composition for relieving cough and reducing phlegm and a preparation method thereof. Background technique [0002] Cough refers to a disease characterized by exogenous pathogenic factors or internal injuries, leading to loss of ventilation and depletion of the lungs, upward reversal of lung qi, impingement on the airway, coughing sound or accompanied by expectoration. In traditional Chinese medicine, the sound without phlegm is called cough, the presence of phlegm without phlegm is called cough, and the sound of phlegm is called cough. Clinically, phlegm sounds are mostly seen together, and it is difficult to separate them completely, so they are called together with cough. Cough is one of the most common diseases in internal medicine, and the incidence rate is very high. According to statistics, the incidence rate of chronic cough is 3%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P11/14A61P11/10
CPCA61K36/185A61K36/28A61K36/346A61K36/535A61K36/539A61K36/70A61K36/752A61K36/904A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P11/10A61P11/14A61K2300/00
Inventor 晁恩祥晁燕曾风英王小花王宏图
Owner 北京东方运嘉科技发展有限公司
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