A kind of nano sunscreen based on zein and its preparation method and application

A technology of zein and zein, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve safety problems, reduce the photoprotective performance of organic sunscreens, etc., and achieve high encapsulation efficiency, Reduce the possibility of dissolution and transdermal, the effect of large diffusion resistance

Active Publication Date: 2021-04-20
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hydrophilic natural polymers need to be chemically cross-linked after encapsulation to form a three-dimensional structure to reduce the leakage of embedded substances, and the residue of these chemical cross-linked substances will cause a series of safety problems
At the same time, there is incompatibility between hydrophilic natural polymers and hydrophobic organic sunscreens on the molecular scale, thus greatly reducing the photoprotective performance of organic sunscreens

Method used

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  • A kind of nano sunscreen based on zein and its preparation method and application
  • A kind of nano sunscreen based on zein and its preparation method and application
  • A kind of nano sunscreen based on zein and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0038] The preparation of embodiment 1 cinnamate / Zein nano sunscreen

[0039] Firstly, 2.5 g of zein and 1 g of 2-ethylhexyl 4-methoxycinnamate (OMC) were dissolved in 50 ml of 80% ethanol aqueous solution, and stirred at room temperature for 2 hours to fully dissolve. Under the condition of stirring at 1000rpm, the above mixed solution was slowly added dropwise to deionized water through a constant flow pump, and the dropwise addition was completed within 12 hours. The concentration in the solution reaches 1%. Centrifuge at 4000rpm for 10 minutes to remove large particles, and the obtained emulsion is the cinnamate / Zein nano sunscreen aqueous dispersion. The product looks like figure 1 As shown, the particle size is 100-200nm. Wherein the mass of OMC is 15% of the protein mass.

[0040] The light protection performance test is determined by ultraviolet-visible absorption spectrometry. The scanning range is 250-400nm. Test samples included organic sunscreens dissolved in...

Embodiment 2

[0042] The preparation of embodiment 2 Avobenzone / Zein nano sunscreen

[0043]Weigh 1.0 g of butylmethoxydibenzoylmethane (Avobenzone) in a beaker, weigh 3 g of zein into the beaker, add 50 ml of ethanol aqueous solution with a mass concentration of 85%, and stir to obtain a uniform yellow transparent homogeneous solution; Under strong stirring, slowly add the ethanol aqueous solution of the above mixture into deionized water with a constant flow pump, and the dropwise addition is completed within 24 hours. The concentration in the suspension reaches 1%. Centrifuge at 4000rpm for 10 minutes to remove large particles, and the resulting emulsion is the Avobenzone / Zein nano-sunscreen aqueous dispersion. The obtained sample looks like figure 2 shown. Wherein the quality of Avobenzone is 20% of protein Zein quality.

Embodiment 3

[0044] The preparation of embodiment 3 Oxybenzone / ZIF-8 nano sunscreen

[0045] Weigh 5.6g of 2,2'-dihydroxy-4-methoxybenzophenone (Oxybenzone) in a beaker, weigh 10g of zein into the beaker, add 100ml of acetone aqueous solution with a mass concentration of 85%, and stir Obtain a uniform yellow transparent solution in 2 hours; under strong stirring, slowly add the ethanol aqueous solution of the above mixture into deionized water with a constant flow pump, and the addition is completed within 1 hour. After that, use a high-pressure homogenizer to homogenize for 10 minutes, and then spray Dry to obtain Oxybenzone / Zein nano sunscreen. Wherein the quality of Oxybenzone is 50% of protein Zein quality.

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Abstract

The invention discloses a nano sunscreen based on zein and its preparation method and application. The nano sunscreen includes zein and an organic sunscreen encapsulated by the zein. The zein Solubilizing protein coats the surface of the organic sunscreen. The synthesis conditions of the nano-sunscreen agent are mild, the reaction time is short, and the obtained material can effectively inhibit the direct contact between the organic sunscreen agent and the skin, reduce the direct contact between the organic sunscreen agent and the active oxygen species ROS produced after photoactivation and the skin, and inhibit its Transdermal absorption causes a series of phototoxicity, it is a new type of nano sunscreen material.

Description

technical field [0001] The invention belongs to the field of cosmetics and skin care products, and in particular relates to a novel biologically safe and high-efficiency zein material-encapsulated nano-sunscreen and its synthesis method and application. Background technique [0002] As we all know, the sun can provide the energy needed for life activities for the living things on the earth. However, ultraviolet rays in sunlight often cause a series of biological damage to organisms, such as erythema formation, immunosuppression, oxidative stress, photoaging, DNA and RNA damage, and skin cancer. Therefore more and more people pay attention to the protection of ultraviolet rays. At present, the additives used for skin care photoprotection mainly include inorganic sunscreens and organic sunscreens. Inorganic sunscreens mainly reduce the damage of ultraviolet rays to the skin through the reflection and scattering of ultraviolet rays, while organic sunscreens mainly reduce the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/37A61K8/35A61Q17/04
CPCA61K8/35A61K8/37A61K8/645A61Q17/04
Inventor 骆丹徐丽贤
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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