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An antibacterial gynecological external pharmaceutical composition and its preparation method and application

A technology of externally applied medicine and composition, applied in the field of antibacterial gynecological externally used pharmaceutical composition and its preparation, which can solve the problems that the efficacy of medicine needs to be improved, the complications of gynecological inflammation cannot be treated, and the inhibitory effect of Gram-positive bacteria is not ideal.

Active Publication Date: 2021-04-20
HUBEI XIANGRUIFENG ECOLOGICAL FRUIT IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition has the disadvantage that yew has an unsatisfactory inhibitory effect on Gram-positive bacteria, and basically cannot treat gynecological inflammation complications, and the drug effect needs to be improved.

Method used

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  • An antibacterial gynecological external pharmaceutical composition and its preparation method and application
  • An antibacterial gynecological external pharmaceutical composition and its preparation method and application
  • An antibacterial gynecological external pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The formula of embodiment 1 antibacterial gynecological external pharmaceutical composition

[0032] 1. Exploration of ingredients of antibacterial gynecological topical pharmaceutical composition

[0033] (1) Prepare the extract of active ingredients of traditional Chinese medicine

[0034]The Chinese medicine extract is prepared according to the following steps: ①after the yew, flavescens, baicalin and cnidium are dried, they are respectively pulverized by a pulverizer to obtain the powder of the Chinese medicine, and the diameter of the powder is controlled to be 60-80 mesh; ②Take the powder of the Chinese medicine respectively material, adding water 5 times the amount of material to extract; leaching 3 times, 5h each time, to obtain the Chinese herbal medicine extract, the extraction temperature is adjusted according to different Chinese herbal medicines; ③ the Chinese herbal medicine extract obtained in step 2 Put it into a circulating vacuum concentration tank to...

Embodiment 2

[0056] Embodiment 2: Preparation of antibacterial gynecological external use pharmaceutical composition

[0057] 1. Investigation of the extraction process

[0058] 1. The inventor investigated the ratio of solid to liquid (1:5, 1:10, 1:15), extraction temperature (50°C, 60°C, 70°C, 80°C), extraction times (1, 2, 3) The influence on the extraction yield and the bacteriostasis of the extract, combined with the extraction cost, proposed an economical and efficient extraction process, that is, the ratio of solid to liquid is 1:5, and the extraction is divided into three times; the extraction temperature, the extraction temperature of yew is 60 ℃, and the extraction temperature of Scutellaria baicalensis, Cnidium fruit and Sophora flavescens is 75 ℃.

[0059] 2. Effect of single extraction and mixed extraction on antibacterial

[0060] 1. The preparation steps of the extracts of yew, flavescens, baicalin and cnidium: ① After the yew, flavescens, baicalin and cnidium are dried, t...

Embodiment 3

[0066] The preparation of embodiment 3 lotions

[0067] The extract of active ingredients of the traditional Chinese medicine is prepared, comprising 8-15 parts of the pharmaceutical composition, 0.1-0.5 parts of menthol, 0.1-0.5 parts of borneol, and 1-3 parts of ethanol.

[0068] As one of the above embodiments, 14 parts of the pharmaceutical composition (6 parts of yew extract, 4 parts of Scutellaria baicalensis extract, 2 parts of Cnidium fruit extract, 2 parts of Sophora flavescens extract), 0.1 part of menthol, 0.1 part of borneol, 2 parts ethanol.

[0069] Follow the steps below:

[0070] (1) After the yew, scutellaria baicalensis, Sophora flavescens and Fructus Cnidii are dried, they are pulverized by a pulverizer respectively to obtain Chinese medicinal material powder, and the diameter of the powder material is controlled to be 60-80 mesh;

[0071] (2) Take 10 parts of Chinese herbal medicine powder respectively, add 5 times the amount of water for leaching; leachi...

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Abstract

The invention discloses an antibacterial gynecological external pharmaceutical composition and its preparation method and application. The pharmaceutical composition comprises the following substances in parts by weight: 1-10 parts of yew extract, 1-10 parts of Scutellaria baicalensis extract, Sophora flavescens 0.5-5 parts of extract, 0.5-5 parts of Fructus Cnidii extract. The application of the present invention includes different dosage forms. The dosage forms include the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. The dosage forms are lotion, gel, and vaginal effervescent tablets. The antibacterial gynecological external pharmaceutical composition of the present invention uses yew as the monarch drug, Scutellaria baicalensis as the minister drug, and cnidium fruit and flavescens, which not only ensures the antibacterial and anti-inflammatory effects of the compound Chinese medicine composition, but also can clear away heat and dampness, and kill insects. It can relieve itching, dissipate stagnation and reduce swelling, improve drug efficacy, shorten recovery time, and improve quality of life. The invention has the advantages of simple preparation process and uniform and stable drug quality.

Description

technical field [0001] The invention relates to the technical field of gynecological medicines, in particular to an antibacterial gynecological external pharmaceutical composition and its preparation method and application. Background technique [0002] Gynecological inflammation is the most common disease in women, mainly referring to the inflammation of female genitalia. Acute and chronic inflammation can occur in various organs of women, specifically including female vulvitis, vaginitis, cervicitis, and pelvic inflammatory disease; according to pathogens, it can be divided into It is fungal vaginitis, bacterial vaginosis and trichomonal vaginitis, which have the characteristics of high incidence, difficult cure and easy recurrence. [0003] With the change of lifestyle, accelerated work pace, decreased immunity and other factors, the incidence of gynecological inflammation continues to rise, and it shows a younger trend. Gynecological inflammation not only affects women'...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61P15/00A61P15/02A61P29/00A61P31/04A61P31/10A61P33/02
CPCA61K36/13A61K36/234A61K36/489A61K36/539A61K2236/331A61K2236/51A61P15/00A61P15/02A61P29/00A61P31/04A61P31/10A61P33/02A61K2300/00
Inventor 李晓胡亮亮
Owner HUBEI XIANGRUIFENG ECOLOGICAL FRUIT IND CO LTD
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