Hyperlipidemia and atherosis treating drug combination

A composition and drug technology, applied in the directions of drug combination, active ingredients of heterocyclic compounds, drug delivery, etc., can solve the problems of unknown pharmacodynamic material basis, lack of controlled research, poor controllability of preparation quality, etc., and achieve the treatment of hyperlipidemia. and atherosclerosis, regulate hyperlipidemia, reduce the effect of fatty plaque area

Active Publication Date: 2018-11-13
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are problems such as unknown substance basis of drug efficacy, poo...

Method used

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  • Hyperlipidemia and atherosis treating drug combination
  • Hyperlipidemia and atherosis treating drug combination
  • Hyperlipidemia and atherosis treating drug combination

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0069] Weigh 200g of kudzu root, 100g of Radix Astragali and 100g of Cortex Mori, add 8 times the amount of water, soak for 30 minutes, decoct and extract twice, each decoction time is 2 hours, combine the two extracts, filter, reduce Concentrate under pressure to a relative density of 1.27 (55°C), dry and pulverize the thick paste to obtain the extract.

preparation Embodiment 2

[0071] Weigh 100g of kudzu root and 200g of astragalus, add 10 times the amount of water, soak for 30 minutes, decoct and extract twice, each decoction time is 1.5 hours, combine the two extracts, filter, and concentrate under reduced pressure to relative density 1.26 (55°C), the thick paste was dried and pulverized to obtain the extract.

preparation Embodiment 3

[0073] Preparation of Puerarin

[0074] Put 800g of kudzu root medicinal material, add 8 times the amount of 50% ethanol solution, heat and reflux to extract twice, each time for 1.5h, combine the extracts and filter, recover the ethanol from the filtrate under reduced pressure, continue to concentrate under reduced pressure to 800ml, and load the concentrated extract on AB-8 macroporous resin, statically adsorbed for 3 hours, washed with deionized water until colorless, and then eluted with 70% ethanol of 4 times the column volume, collected the 70% ethanol eluate, and concentrated under reduced pressure. The above-mentioned concentrated extract was separated by silica gel column chromatography, gradient eluted with a mixed solution formed of dichloromethane and methanol at a volume ratio of 1:0 to 0:1, and detected by thin layer chromatography, and the collected puerarin-containing fractions. The above fractions of puerarin were separated and purified by Sephedex LH-20 gel ...

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Abstract

The invention discloses a hyperlipidemia and atherosis treating drug combination. The hyperlipidemia and atherosis treating drug combination comprises an active component and a medically acceptable carrier, wherein the active component is a combination of two or more of puerarin, daidzin, genistin, calycosin-7-glucoside, astragaloside II, astragaloside, formononetin, mulberroside A, morusin, scopoletin, sanggenone C, 1-deoxynojirimycin, peuraria polysaccharides, astragalus polysaccharides and cortex mori polysaccharides. The hyperlipidemia and atherosis treating drug combination can reduce thearea of fatty plaques in the aorta of an atherosis model of an apoE-/-transgenic mouse, and achieve the effects of adjusting hyperlipidemia of the mouse, thereby being capable of curing hyperlipidemia and atherosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperlipidemia and atherosclerosis, a preparation method and application thereof. More specifically, the present invention relates to a compound pharmaceutical composition of active ingredients in Pueraria Radix, Radix Astragali and Cortex Mori, and its use in the preparation of medicines for treating hyperlipidemia and atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a chronic arterial disease that can cause coronary heart disease, myocardial infarction and other cardiovascular and cerebrovascular diseases as well as stroke. frequently-occurring disease. In developed countries and some developing countries, the incidence of atherosclerotic cardiovascular disease is increasing year by year, and it has become the underlying disease of many common diseases of middle-aged and elderly people, known as the "number one killer". AS lesions mainly occur in the intima of ...

Claims

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Application Information

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IPC IPC(8): A61K36/488A61K36/605A61K31/352A61K31/715A61K31/7048A61K31/7034A61K31/37A61K31/445A61P3/06A61P9/10
CPCA61K31/352A61K31/37A61K31/445A61K31/7034A61K31/7048A61K31/715A61K36/481A61K36/488A61K36/605A61K2236/51A61K2236/39A61K2236/331A61K9/08A61K9/20A61K9/48A61K31/365A61K31/435A61K31/7028A61P3/06A61P9/10
Inventor 黄成钢李志雄高羽田小亭孙兆林陈明苍胡培刘欢徐洲
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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