Industrial production method of intestinal tract probiotic preparation

Abstract

The invention provides an industrial production method of an intestinal tract probiotic preparation. The industrial production method comprises the following steps of (1) performing mass culture on lactobacillus casei, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus acidophilus, streptococcus thermophilus, lactobacillus delbrueckii subspecies bulgaricus and the like through a fermenter; (2) performing centrifuging and washing with sterile water to obtain wet bacterium paste, and uniformly mixing the wet bacterium paste with a special protective agent in the ratio being 1 to 1;and (3) granulating a mixture of the wet bacterium paste and the protective agent, performing rolling to obtain balls, performing low-temperature vacuum drying, and performing coating so as to obtainthe intestinal tract probiotic preparation. Under the culture condition provided by the invention, probiotics can grow and propagate at high density, the collected wet bacterium paste does not need tobe subjected to freeze drying, the wet bacterium paste is directly subjected to vacuum low-temperature quick drying with the special protective agent, and massive bacterium bodies can be maintained to be alive; and energy resources are saved, and the production cost is reduced.

Description

technical field [0001] The invention relates to the field of microbial preparations, in particular to an industrial production method of intestinal probiotic preparations. Background technique [0002] Probiotics refer to single or well-defined mixed microorganisms that change the composition of the flora in a certain part of the host through colonization, thereby producing a beneficial effect on the health of the host. It has beneficial physiological effects on the host by regulating the host mucosal and systemic immune function and improving the balance of intestinal nutrition and flora. Probiotics can be roughly divided into three categories, including Lactobacillus (such as Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus jansnii, Lactobacillus Lamansii, etc.), Bifidobacterium (such as Bifidobacterium longum, Bifidobacterium breve, ovale, bifidobacterium thermophile, etc.), gram-positive cocci (such as faecal streptococcus, lactococcus, intermediary strepto...

AI Technical Summary

Problems solved by technology

[0007] However, in the prior art, when the wet bacteria slime is processed, steps such as freeze-drying that require high equipment and high energy consumption are often required, and it will also cause the death of a large number of bacteria and reduce the overall vitality of the bacteria, thereby The disadvantage of low number of viable bacteria in probiotic preparations

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