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Method for producing RNA molecule compositions

A technology of DNA molecules and compositions, applied in the direction of biochemical equipment and methods, antisense single-stranded RNA virus, microorganism measurement/inspection, etc., can solve expensive and laborious problems

Pending Publication Date: 2018-11-09
CUREVAC AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Routine production of multivalent vaccines containing multiple antigens or RNA molecule compositions in the conventional sense requires multiple runs to generate DNA templates (e.g., plasmid DNA) and RNA, which is laborious and expensive

Method used

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  • Method for producing RNA molecule compositions
  • Method for producing RNA molecule compositions
  • Method for producing RNA molecule compositions

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Embodiment Construction

[0147] In order to solve the above-mentioned problems in the art, the invention provides the method for producing the ribonucleic acid (RNA) molecule composition that comprises n different RNA molecule types, the method may further comprise the steps:

[0148] a) RNA in vitro transcription of a mixture of m different deoxyribonucleic acid (DNA) molecular species in parallel (i.e. simultaneously) in a single reaction vessel, wherein each of the m different DNA molecular species encodes n different RNA molecules one or more of the species, thereby producing n different RNA molecule species, and

[0149] b) Obtaining an RNA molecule composition comprising n different RNA molecule species produced in step a), wherein n is an integer of at least 2, and wherein m is an integer of at least 1.

[0150] In a particularly preferred embodiment, each of the n different RNA molecule species encodes a different peptide or protein, preferably an antigen as mentioned below. In a very preferr...

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Abstract

The invention relates to a method for producing a ribonucleic acid (RNA) molecule composition comprising n different RNA molecule species, the method comprising a step of RNA in vitro transcription ofa mixture of m different deoxyribonucleic acid (DNA) molecule species in a single reaction vessel in parallel, i.e. simultaneously, and a step of obtaining the RNA molecule composition. Also providedis the RNA composition provided by the inventive method and a pharmaceutical composition comprising the same as well as a pharmaceutical container. Moreover, the invention provides the RNA composition and the pharmaceutical composition for use as medicament.

Description

technical field [0001] The present invention relates to the method for producing ribonucleic acid (RNA) molecular composition, and this ribonucleic acid molecular composition comprises n kinds of different RNA molecular species, and this RNA molecular species is derived from m different deoxyribonucleic acid (DNA) molecular species, said The method comprises performing in vitro RNA transcription of a mixture of m different DNA molecular species in a single reaction vessel, wherein each of the m different DNA molecular species encodes one or more of n different RNA molecular species, thereby producing n different RNA molecule species, and obtaining a RNA molecule composition comprising n different RNA molecule species, where n is an integer of at least 2, and wherein m is an integer of at least 1. The present invention also provides the RNA molecular composition produced by the above method, as well as a pharmaceutical composition and a pharmaceutical container comprising the R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K39/00A61K48/00C12N15/11
CPCA61K38/00C07K14/005C12Q1/6844A61K2039/53A61K2039/70C12N2760/16111C12N2760/16122C12N2760/16134C12N2760/16222C12N2760/16234A61K39/12A61P21/00A61P31/00A61P39/00Y02A50/30C12Q2521/119C12N15/1024C40B10/00C40B40/02C40B40/08
Inventor 蒂尔曼·鲁斯马丁·孔泽本雅明·亚兹丹·潘纳萨利赫·耶尔马兹马库斯·康策尔曼
Owner CUREVAC AG
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