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A slow-release multi-layer dental implant and its preparation method and evaluation method

An evaluation method and implant technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of sealing effect, mechanical strength and long-term treatment, food residues, etc. Into the cavity, foreign body sensation in the filling part, etc., to achieve suitable mechanical strength, long-term maintenance of drug effect, and good sealing effect

Active Publication Date: 2021-07-23
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sealing effect, mechanical strength and long-term treatment of cotton balls and pastes are not ideal
The following situations are prone to occur: 1) The filler falls, and food residue enters the cavity; 2) The drug is infiltrated and eluted by oral saliva, causing bitter taste in the mouth or toxic side effects of the gastrointestinal tract, and the concentration of the drug in the cavity is insufficient, so there is no long-term effect ;3) There is a foreign body sensation at the filling site, and the filling moves during chewing, which stimulates the locally exposed dental nerves and causes pain
So far, there is no relevant report that discloses that there are slow-release implants that can be used for 1-2 weeks of disinfection and temporary filling in dental cavities

Method used

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  • A slow-release multi-layer dental implant and its preparation method and evaluation method
  • A slow-release multi-layer dental implant and its preparation method and evaluation method
  • A slow-release multi-layer dental implant and its preparation method and evaluation method

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Experimental program
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Effect test

Embodiment 1

[0038] Embodiment 1 Preparation of mould, release mould, pressurized mould

[0039]3D scanning was used to obtain dental caries information, SolidWorks software was used to design molds, polylactic acid was used as material, and corresponding preparation molds, release molds and compression molds were printed by fused deposition modeling. The nozzle diameter is 0.4mm, the printing temperature is 190°C, the printing speed is 45mm / s, and the layer height is 0.10mm. figure 1 Typical prepared mold, released mold and compressed mold appearances.

Embodiment 2

[0040] Embodiment 2 prepares three-layer implant, and concrete steps are as follows:

[0041] S1: Select the prepared mold B in Example 1.

[0042] S2: 100 parts of ethyl cellulose and 15 parts of triethyl citrate, physically mix, grind evenly, take 80 mg as the first layer material; 10 parts of chlorhexidine, 61 parts of ethyl cellulose, 19 parts of triacetin and 10 parts of HPMC-E5, mixed evenly, hot-melt extruded (90°C, 60rpm, 10min), and 50mg was taken as the second layer of material. 30 parts of chlorhexidine, 60 parts of polyvinyl alcohol and 10 parts of glycerol triacetate were mixed uniformly, hot-melt extruded (85°C, 50 rpm, 10 min), and 50 mg was taken as the third layer material.

[0043] S3: Assemble 1 / 2 of the preparation mold, add the materials of the three layers into the preparation mold respectively for hot pressing (90°C, 5kg, 2min), and divide the 1 / 2 preparation mold to obtain a three-layer implant. look like figure 2 shown.

Embodiment 3

[0044] Embodiment 3 prepares double-layer implant, concrete steps are as follows:

[0045] S1: For different three-dimensional caries models, print different forms of preparation molds.

[0046] S2: 100 parts of cellulose acetate and 20 parts of triethyl citrate, physically mix, grind evenly, take 70mg, 90mg and 130mg respectively as the first layer material of 1#-3#; 25 parts of chlorhexidine, cellulose acetate 50 parts, 5 parts of glycerol triacetate and 20 parts of HPMC-E5, mixed evenly, hot-melt extruded (100°C, 60rpm, 10min), 20mg, 30mg and 80mg were taken as the second layer of 1#-3#.

[0047] S3: Combine 1 / 2 of the preparation molds, add the two layers of materials into the preparation molds for hot pressing (80°C, 3kg, 3min), divide 1 / 2 of the preparation molds, and make 1#-3# different shapes and sized bilayer implants that look like image 3 shown.

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Abstract

The invention provides a slow-release multi-layer dental implant and its preparation method and evaluation method. The implant consists of three parts: the first layer, the second layer and the third layer or simplified into two parts: the first layer and the second layer. The three-dimensional size coincides with the middle of the hole, the thickness is >1.5mm, the third layer is conical, and there is a 0.1-0.5mL gap with the bottom of the hole. The beneficial effects of the present invention are: the multi-layer dental implant has good sealability, suitable mechanical strength and long-term treatment effects, and does not use adhesives, and is easy to take out after use; its preparation process Convenient, intuitive and adjustable, fast and cheap, patients can get the implant on the spot and try out the effect and adjust the surface morphology; the provided in vitro evaluation method of multi-layer dental implant can be used to optimize the prescription of the implant technology, or supplement expert design database information for doctors to refer to for future reference.

Description

technical field [0001] The invention belongs to the field of dental implants, and in particular relates to a slow-release multilayer dental implant and its preparation method and evaluation method. [0002] technical background [0003] Dental caries is a common disease in the Department of Stomatology. It is mainly treated by filling and restoration. The whole treatment process includes three steps: "removing caries and opening holes", "sterilizing and anti-inflammatory" and "permanent filling". Because the caries is complicated, the "sterilization and anti-inflammation" step needs to last for 1-2 weeks. It not only requires that the anti-bacterial and anti-inflammatory drugs can be released slowly and have a long-term effect; diet. [0004] At present, clinical medicine is mostly sealed by hand. For example: cotton balls containing camphorol solution, or calcium hydroxide paste, are manually filled in the cavity. However, the sealing effect, mechanical strength and long-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/38A61K31/155A61P31/02A61P1/02G01N3/08G01N33/15
CPCA61K9/0024A61K31/155A61K47/38A61P1/02A61P31/02G01N3/08G01N33/15G01N2203/0019
Inventor 杨燕李海超单伟光
Owner ZHEJIANG UNIV OF TECH
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