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Traditional Chinese medicine particle for treating spleen-kidney insufficiency type IgA kidney disease as well as preparation method and application of traditional Chinese medicine particle

A technology of spleen and kidney yang deficiency type, traditional Chinese medicine granules, applied in the directions of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as the extraction process of undisclosed water-extracted preparations

Active Publication Date: 2018-10-30
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The document "Exploring the Kidney Protection Mechanism of Huangqi Guizhi Wuwu Decoction on IgA Nephropathy Mice Based on NLRP3 Inflammasome" discloses the dry powder of water extraction preparation of Huangqi Guizhi Wuwu Decoction, but does not disclose the specific extraction process of water extraction preparation

Method used

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  • Traditional Chinese medicine particle for treating spleen-kidney insufficiency type IgA kidney disease as well as preparation method and application of traditional Chinese medicine particle
  • Traditional Chinese medicine particle for treating spleen-kidney insufficiency type IgA kidney disease as well as preparation method and application of traditional Chinese medicine particle
  • Traditional Chinese medicine particle for treating spleen-kidney insufficiency type IgA kidney disease as well as preparation method and application of traditional Chinese medicine particle

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 drug efficacy experiment screening optimal process route

[0025] In this example, the extracts of the three process routes of Huangqi Guizhi Wuwu Decoction were prepared respectively: water extraction, water extraction and alcohol precipitation samples, and cinnamon twig single extraction volatile oil samples, and the main pharmacodynamic indicators for the treatment of IgA nephropathy were investigated to determine the best process route.

[0026] 1 material

[0027] "Wuwutang" water extraction preparation was prepared by Shanghai Traditional Chinese Medicine Pharmaceutical Technology Co., Ltd. "Wuwutang" water extraction and alcohol precipitation preparation was prepared by Shanghai Traditional Chinese Medicine Pharmaceutical Technology Co., Ltd. "Wuwutang" Guizhi single extraction volatile oil preparation was prepared by Shanghai Traditional Chinese Medicine Pharmaceutical Technology Co., Ltd.

[0028] 2 methods and steps

[0029] 100 BALB / c mice we...

Embodiment 2

[0074] Embodiment 2 extraction process parameter optimization

[0075] The water extraction was determined to be the best extraction route through drug efficacy screening experiments. The water extraction process parameters of "Wuwutang" were optimized with the amount of water added, extraction time and extraction times as the main factors, and the evaluation indexes of dry extract yield and effective component transfer rate. build L 9 (3 4 ) Orthogonal design experiment, weighing the medicinal materials according to the prescription, carrying out the extraction, concentration and drying of the medicinal materials according to the orthogonal test table.

[0076] 1 Investigation on soaking time of medicinal materials

[0077] 1.1 Method

[0078] The optimal soaking time is determined by examining the water absorption rate of medicinal materials. Weigh 9g of astragalus, 9g of cassia twig, 9g of white peony, 18g of ginger, and 12g of jujube, 6 parts in total, put them in a b...

Embodiment 3

[0131] Embodiment 3 preparation process research

[0132] 1 dosage form selection

[0133] The compound was originally used clinically in the form of decoction, but the decoction has defects such as difficulty in preservation and inconvenience in carrying, which limits its wide application in treatment. At present, traditional Chinese medicine preparations are often made into dosage forms such as tablets, capsules, oral liquids, syrups, injections, and granules for clinical use. In order to not only retain the characteristics of traditional Chinese medicine, but also to extract and retain the active ingredients in the prescription to the maximum extent, to exert the comprehensive therapeutic effect of the active ingredients, and to ensure the clinical efficacy, granules were finally selected.

[0134] 2 Granulation process research

[0135] 2.1 Selection of granulation process

[0136] The drug adopts a one-step granulation process. The powder raw material can be added with...

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Abstract

The invention relates to technical field of traditional Chinese medicines and particularly discloses a traditional Chinese medicine particle for treating spleen-kidney insufficiency type IgA kidney disease as well as a preparation method and application of the traditional Chinese medicine particle. Based on traditional application of radix astragali-cassia twig five-component soup, different extraction and purification process routes are compared and investigated under the guidance of a traditional Chinese medicine theory according to the monarch, minister, assistant and guide rules of traditional Chinese medicines in a prescription and an effective component group, and an optimal extraction route is optimally selected from pesticide effect screening experiments; by comprehensively utilizing testing methods of orthogonal test, single factor investigation and the like, the influences caused by a pretreatment method, extraction process parameters (extraction time, extraction number of times and solvent adding amount and the like), a purification method and relevant parameters of medicinal materials on the yield and purity of the index components in the radix astragali-cassia twig five-component soup are compared and analyzed, and optimal process parameters are obtained; and by researching a preparation process, the dose form and a preparation method are determined; and by carrying out trial production on three batches of pilot test samples, the process amplification has stability and feasibility.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to traditional Chinese medicine granules for treating spleen and kidney yang deficiency type IgA nephropathy, a preparation method and application thereof. Background technique [0002] IgA nephropathy (immunoglobulin A nephropathy, IgAN) is the most common primary glomerular disease in the world, accounting for 25%-50% of primary glomerulonephritis, with hematuria and proteinuria as the main clinical manifestations, the main pathological features It is the proliferation of glomerular mesangial cells and increased matrix, accompanied by the deposition of IgA-based immune complexes, which is an important cause of end-stage renal failure. Because the pathogenesis of IgAN is still unclear, there is currently no specific therapy for IgAN. The main method is to use ACEI / ARB drugs to reduce proteinuria and hypertension in patients according to the 2012 Kidney Disease...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61P13/12
CPCA61K9/1652A61K36/481A61K36/54A61K36/65A61K36/71A61K36/725A61K36/9068A61K2236/331A61K2236/39A61K2236/51A61P13/12A61K2300/00
Inventor 高建东徐琳管鑫杨雨竹吴燕升刘伟伟王琛黄迪
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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