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Targeting multifunctional nanoparticle wrapping IR780 and application and preparation method thereof

A multifunctional nanoparticle technology, applied in the field of biomedicine, can solve the problems of easy tumor recurrence and poor treatment effect, and achieve the effect of good dispersion, uniform size and regular shape

Inactive Publication Date: 2018-10-26
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] One of the objectives of the present invention is to provide a targeted multifunctional nanoparticle loaded with IR780 to solve the problems in the prior art that the tumor is prone to recurrence and the treatment effect is not good due to the uneven distribution of the nanoparticle in the tumor site

Method used

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  • Targeting multifunctional nanoparticle wrapping IR780 and application and preparation method thereof
  • Targeting multifunctional nanoparticle wrapping IR780 and application and preparation method thereof
  • Targeting multifunctional nanoparticle wrapping IR780 and application and preparation method thereof

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Embodiment Construction

[0044] The following is further described in detail through specific implementation methods:

[0045] The embodiment is basically as attached Figure 1 to Figure 8 Shown:

[0046] 1. The preparation method of the targeted multifunctional nanoparticles carrying IR780 of the present invention, the specific steps are as follows:

[0047] (1) Preparation of PLGA-NHS: Weigh 100mg PLGA-COOH and dissolve in 4ml DCM, take 0.4mM NHS and 0.3mMDCC and dissolve in 2ml DCM, then mix the two, stir and react at 37°C for 12 hours; add 80ml after dialysis overnight Mixed solution of ice methanol and ether (volume ratio 1:1), put it in a refrigerator at 4°C for 24 hours, centrifuge to collect the precipitate, wash the precipitate and dry it in vacuum to obtain a white solid PLGA-NHS;

[0048] (2) Preparation of PLGA-PEG-COOH: Dissolve 0.02mM PLGA-NHS in 20ml DCM, weigh 0.2mM DIEA, 0.4mM DIEA and 0.05mM NH2-PEG-COOH, add to the above solution, and stir at 37°C for reaction 12 hours; dialyze f...

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Abstract

The invention relates to the technical field of biological medicine and discloses a targeting multifunctional nanoparticle wrapping IR780. The targeting multifunctional nanoparticle comprises a polylactic acid-glycolic acid copolymer PLGA shell and the IR780 iodide embedded into the polylactic acid-glycolic acid copolymer PLGA shell, wherein a cyclic arginyl-glycyl-aspartic acid cRGD targeting peptide fragment is connected to the polylactic acid-glycolic acid copolymer PLGA shell. By the targeting multifunctional nanoparticle, the problems that tumor is prone to relapse and the treatment effect is poor due to the fact that the nanoparticles are not uniformly distributed on a tumor part in the prior art are solved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a targeted multifunctional nanoparticle carrying IR780, its application and its preparation method. Background technique [0002] With the continuous development of medical imaging, a single imaging method is no longer enough to meet the increasing diversification needs of modern medicine, and multimodal contrast agents have emerged as the times require, which has changed the traditional single imaging mode of contrast agents. A non-invasive medical imaging method developed in recent years, which combines the high contrast characteristics of pure optical imaging and the high penetration depth characteristics of pure ultrasound imaging, can provide high-resolution and high-contrast tissue imaging, and its outstanding It is characterized by the ability to display tissues and identify the differences in tissues according to the light absorption threshold of different components,...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61K49/22A61K9/51A61K47/34A61K47/18A61P35/00
CPCA61K9/5123A61K9/5153A61K41/0052A61K49/0032A61K49/0093A61K49/223A61P35/00
Inventor 刘明珠
Owner CHONGQING MEDICAL UNIVERSITY
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