A biomimetic hollow silica composite particle modified by β-1,3-d-glucan and its application
A silicon dioxide and composite particle technology, applied in the field of vaccine adjuvants and drug carriers, can solve the problems of lack of biological activity on the surface, fast drug release speed, and low drug load, so as to improve the utilization rate of antigens, reduce toxic and side effects, The effect of low production cost
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[0053] A biomimetic hollow silica composite particle modified by β-1,3-D-glucan, according to figure 1 The process shown is prepared, and the specific preparation process is as follows:
[0054] (1) Preparation of bacteria-based biomimetic hollow silica particles with nanotransport channels
[0055] Most bacteria can be used as soft templates for the preparation of hollow silica particles. In this example, two common bacteria (E. Biomimetic hollow silica particles.
[0056] Take 1.8mL of 8×10 10 Individual / mL Escherichia coli or Staphylococcus aureus aqueous solution to the flask, then add 5mL of 25% ammonia water, then add 73.2mL absolute ethanol, ultrasonically mix for 10min; under magnetic stirring, add 2.23mL orthosilicic acid drop by drop The mixture of ethyl ester and 17.77mL ethanol solution was reacted at room temperature for 72h; after the reaction was completed, the obtained particles were collected by centrifugation at 4000rpm for 10min, and the obtained particle...
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