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Chlorin e6-lentinan ester and preparation method thereof

A technology of chlorin and lentin, which is applied in directions such as pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as no reports on lentin and chlorphene, etc., Achieve anti-tumor effect, good effect

Inactive Publication Date: 2018-10-12
桂林市兴达光电医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no report on the combination of lentinan and chlorin e6

Method used

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  • Chlorin e6-lentinan ester and preparation method thereof
  • Chlorin e6-lentinan ester and preparation method thereof
  • Chlorin e6-lentinan ester and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0026] Chlorin e6 (Chlorin e6, Ce6) is dissolved in ethanol under the condition of protective gas and dark, and it is A. Lentinan was dissolved in hot water at 50-80°C, then A was added, and reacted for 32 hours under stirring at room temperature; wherein chlorin e6 (Chlorin e6, Ce6) and lentinan were in equimolar amounts.

[0027] After centrifugation, the supernatant was dialyzed against deionized water and freeze-dried.

[0028] The dry matter is separated by silica gel column chromatography, and the eluent is a mixed solution of dichloromethane / methanol with a volume ratio of 3 / 7 to 7 / 3;

[0029] After dichloromethane / methanol is evaporated, dissolve with methanol or acetonitrile, refine and purify with reverse phase column chromatography, the eluent is methanol / water mixed solution or acetonitrile / water mixed solution; the filler used in the reversed phase column is C 18 ; The volume ratio of the methanol / water mixed solution or the acetonitrile / water mixed solution is 3...

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PUM

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Abstract

The invention discloses a chlorin e6-lentinan ester and a preparation method thereof. The chlorin e6-lentinan ester is prepared by the esterification reaction between the lentinan and the chlorin e6,and the lentinan is the polar end of soluble in the water, so that the chlorin e6-lentinan ester is dissolved in water to solve the problem of poor water solubility of Ce6, and has the double anti-tumor effect of the chlorin e6 and the lentinan, and belongs to the field of light and sound power treatment medicaments, and can be used for preparing medicaments for treating skin diseases, malignant tumors or cancerous pleural and abdominal water.

Description

technical field [0001] The invention relates to light and sound dynamic therapy drugs, in particular to chlorin e6-lentinan ester. Background technique [0002] Chlorin e6 (Chlorin e6, Ce6), dark green powder, very hygroscopic and easy to oxidize. Insoluble in water, soluble in acetone, tetrahydrofuran, ethanol. [0003] Chlorin e6 has certain photosensitivity and thermosensitivity, so chlorin e6 is not only a photosensitizer, but also a potential sound sensitizer. It has an absorption wavelength of 663nm, can generate more ROS (reactive oxygen species), and is non-toxic, has high selectivity for tumor tissue and high clearance rate for non-tumor tissue, and has less side effects on the skin, so it is suitable for use in tumors Light and sound dynamic therapy. However, Ce6 has poor water solubility, which limits its clinical development and application. [0004] Lentinan (LNT) is an effective active ingredient extracted from high-quality mushroom fruiting bodies. It is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K41/00A61K47/55A61P35/00A61P17/12A61P17/10A61P17/00A61K31/715
CPCA61K31/715A61K41/0071A61K47/55A61P17/00A61P17/10A61P17/12A61P35/00C08B37/0024A61K2300/00
Inventor 陈志强
Owner 桂林市兴达光电医疗器械有限公司
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