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Zebrafish vestibular eye movement reflex tester and its testing method

A technology of reflex testing and zebrafish, applied in veterinary instruments, diagnostic recording/measurement, equipment for restraining animals, etc., can solve problems such as damage to zebrafish nerves and test result errors

Inactive Publication Date: 2021-05-28
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the vestibular eye movement reflex test system, how to fix the zebrafish is very important. One of the fixation methods is to anesthetize the zebrafish on the culture droplet on the cover glass. The anesthesia makes the zebrafish fix on the cover glass, but the anesthetic damages the zebrafish. nerves and easily lead to errors in test results

Method used

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  • Zebrafish vestibular eye movement reflex tester and its testing method
  • Zebrafish vestibular eye movement reflex tester and its testing method
  • Zebrafish vestibular eye movement reflex tester and its testing method

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Embodiment Construction

[0032] Such as figure 1 and figure 2 As shown, the zebrafish vestibular eye movement reflex tester 10 provided in this implementation includes a zebrafish fixing device 12, a rotating device 14 and an infrared imaging device 16, the zebrafish fixing device 12 is used to fix the zebrafish 20, and the rotating device 14 is used for The zebrafish fixing device 12 on which the zebrafish 20 is fixed is controlled to rotate, and the infrared imaging device 16 is used to capture the head image of the rotating zebrafish 20 .

[0033] Such as image 3 and Figure 4 As shown, the zebrafish fixing device 12 includes a body 100, specifically, in this embodiment, the body 100 is plexiglass. The body 100 includes opposing mounting surfaces 102 and a working surface 104 . The working surface 104 defines a fixing groove 110 and an accommodating groove 120 , and the fixing groove 110 communicates with the accommodating groove 120 . The fixing groove 110 is used to fix the body 22 of the ...

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Abstract

The invention relates to a zebrafish vestibular eye movement reflex tester and a test method thereof. The tester includes: a rotating device, including a rotating platform; a zebrafish fixing device, including a body on the rotating platform, the body includes a relative installation surface and a working surface, and the working surface is provided with a fixing groove and an accommodating groove, and the fixing groove It communicates with the holding tank, the fixing tank is used to fix the body of the zebrafish, the holding tank is used to accommodate the head of the zebrafish, and the inner wall of the holding tank is spaced from the head of the zebrafish; the infrared imaging device is located at On the rotating platform, the infrared imaging device includes an infrared light source and an infrared camera, the infrared light source is used to irradiate the head of the zebrafish, and the infrared camera is used to obtain the head image of the zebrafish irradiated by the infrared light source. The zebrafish vestibulo-ocular reflex tester does not require anesthesia of the zebrafish, and can eliminate errors caused by anesthesia used to damage the oculomotor muscles in the vestibulo-ocular reflex test, and has high accuracy.

Description

technical field [0001] The invention relates to the technical field of vestibular hearing, in particular to a zebrafish vestibular eye movement reflex tester and a test method thereof. Background technique [0002] Vestibular dysfunction is a disease with high morbidity, many hazards and huge resource consumption, which seriously affects human health. One-third of adults have suffered from this disease, and it has an increasing trend year by year. Vestibular dysfunction not only brings dizziness, balance disorder, secondary hearing loss and other physical discomfort, but also weakens social function and causes psychological and mental disorders. The abuse of ototoxic drugs (ampicillin antibiotics) and environmental pollution have increased the number of people with vertigo year by year, and vertigo has become a global health problem. The auditory hair cell is the common sensory cell of the auditory system and the balance system. Due to the complexity of the inner ear maze o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/12A61B5/00A61D3/00
CPCA61B5/0064A61B5/0077A61B5/125A61B2503/40A61D3/00
Inventor 陈放怡孙鹏廖群刘铭华
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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