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Application of ADAMTS13 to preparation of drugs used for promoting vascular remodeling after stroke

A stroke, purpose technology, applied in the field of biopharmaceuticals

Inactive Publication Date: 2018-10-09
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no report on the effect of ADAMTS13 on angiogenesis in vivo

Method used

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  • Application of ADAMTS13 to preparation of drugs used for promoting vascular remodeling after stroke
  • Application of ADAMTS13 to preparation of drugs used for promoting vascular remodeling after stroke
  • Application of ADAMTS13 to preparation of drugs used for promoting vascular remodeling after stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1 Animal experiment

[0081] 1) Experimental animals

[0082] ADAMTS13 knockout mice (purchased from Jackson Laboratory), VWF knockout mice (purchased from Jackson Laboratory) ADAMTS13 and VWF double knockout mice (ADAMTS13 knockout mice were crossed with VWF knockout mice to obtain F1 generation ADAMTS13 and VWF Double heterozygous mice, male and female pairing of F1 generation mice, screened out F2 generation ADAMTS13 and VWF double gene knockout homozygous mice) are all C57BL / 6 background, and wild-type C57BL / 6 mice age-matched were selected as control mice Rats (provided by Shanghai Slack Experimental Animal Co., Ltd.); all mice used in the experiments were male mice of 8-10 weeks old; all animal experiments complied with the regulations of the Animal Care and Use Committee of the Brain Science Collaborative Innovation Center of Fudan University;

[0083] 2) Distal middle cerebral artery ischemia model

[0084] According to the literature, the cortical ...

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Abstract

The invention relates to application of ADAMTS13 to preparation of drugs for vascular remodeling, especially application of ADAMTS13 to preparation of drugs used for promoting vascular remodeling after stroke, belonging to the field of biopharmacy. The experimental results of the invention prove that the loss of ADAMTS13 leads to decrease in both revascularization and vascular integrity and aggravation of vascular damage in the peripheral cortex of cerebral ischemia mice; exogenous recombinant ADAMTS13 can significantly increase revascularization, promote the repair of vascular functions and improve the behavioral functions of the cerebral ischemic mice; ADAMTS13 plays an important role in regulating revascularization in the recovery phase of cerebral ischemic; inhibition of revascularization and vascular maturation due to the loss of ADAMTS13 may be related to the opening of vascular permeability; and ADAMTS13 promotes vascular remodeling after cerebral ischemia through the VWF-Ang-2 / Gal-3-pVEGFR-2 pathway.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to the use of ADAMTS13 in the preparation of blood vessel remodeling drugs, especially the use of ADAMTS13 in the preparation of drugs for promoting blood vessel remodeling after stroke. Background technique [0002] Studies have shown that stroke is the main long-term disabling disease worldwide. However, there is no effective medical method to promote the recovery of brain function after stroke. Studies have reported that after stroke, there will be continuous nerve regeneration, and these new neural precursor cells will promote the remodeling of brain function by migrating to the periphery of the ischemic injury. Although a large number of reports have proved that stem cell transplantation therapy can promote brain circuit repair and brain function recovery after stroke, the low survival rate and tumorigenesis of stem cells restrict their clinical use. Studies have shown that aft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P9/10
CPCA61K38/4886C12Y304/24
Inventor 范文英赵冰樵徐昊辰曹永亮杨醒
Owner FUDAN UNIV
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