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PEG-free solubilizer and manufacturing method thereof

A technology of solubilizer and solution, applied in the formulation of perfume preparations, preparations for skin care, chemical instruments and methods, etc., can solve problems such as irritation of skin and mucous membranes

Active Publication Date: 2018-10-09
李忠根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] And, although polyethylene glycol (Polyethylene glycol, PEG) is not a carcinogen, there are following problems, that is, the residual substance contained therein is a carcinogen, and ethylene oxide can irritate the skin and mucous membranes.

Method used

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  • PEG-free solubilizer and manufacturing method thereof
  • PEG-free solubilizer and manufacturing method thereof
  • PEG-free solubilizer and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Preparation without polyethylene glycol solubilizer

[0035] (1) A sodium sulfosuccinate solution was prepared by mixing and stirring 25 parts by weight of dipropylene glycol and 18 parts by weight of water with respect to 100 parts by weight of sodium sulfosuccinate represented by the following chemical formula 1-1:

[0036] Chemical formula 1-1:

[0037] In chemical formula 1, R 1 and R 2 Both are 2-ethylhexyl.

[0038](2) A polyethylene glycol-free solubilizer was prepared by thoroughly mixing and stirring 97.5 weight percent of polyglyceryl-10 laurate and 2.5 weight percent of the above-mentioned sodium sulfosuccinate.

Embodiment 2～ Embodiment 4 and comparative example 1～ comparative example 2

[0039] Embodiment 2~Example 4 and Comparative Example 1~Comparative Example 2: Preparation without polyethylene glycol solubilizer

[0040] A polyethylene glycol-free solubilizer was prepared by the same method as in Example 1 above, and was prepared by mixing polyglyceryl-10 laurate and sodium sulfosuccinate so as to have the composition of Table 1 below.

[0041] Table 1

[0042]

preparation example 1 and comparative preparation example 1～ comparative preparation example 2

[0044] After preparing AMARIGE TYPE perfume (perfume) (trade name: SKIN CARE B26089, manufacturer: CFF), mix the non-polyethylene glycol solubilizer and perfume of part a of Example 1 with the composition of the following Table 2 and dipropylene glycol, prepare a mixed solution by stirring well with deionized water from part b.

[0045] And, each mixed solution was prepared with the composition as shown in the following Table 2, and comparative preparation examples 1-2 were respectively implemented.

[0046] Moreover, after fully shaking Preparation Example 1 and Comparative Preparation Examples 1 to 2, the solubilizing effect of the solubilizing agent was confirmed, and the results were as follows: figure 1 shown. At this time, only deionized water was used as a control group.

[0047] Table 2

[0048]

[0049] Such as figure 1 As shown, it was confirmed that Preparation Example 1 was as transparent as the control group, whereas Comparative Preparation Example 1 and Co...

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Abstract

The present invention relates to a PEG-free solubilizer having an optimal composition and composition ratio, which can be used as a solubilizer for making oil and water which are not mixed with each other mix and transparent, and can replace an existing solubilizer composed of an ethoxylated compound.

Description

technical field [0001] The present invention relates to solubilizers, and more particularly to polyethylene glycol (PEG)-free solubilizers that can be used instead of ethoxylated Existing solubilizers composed of base compounds. Background technique [0002] "PEG-60 Hydrogenated Castor Oil", Polyethylene Glycol-40 Hydrogenated Castor Oil (PEG- 40HydrogenatedCastor Oil), polysorbate 20 (Polysorbate 20), polysorbate 60 (Polysorbate 60), polysorbate 80 (Polysorbate 80), olive oil PEG-7 ester (OLIVE OIL PEG-7ESTERS)" are all Ethoxylated products. [0003] Ethoxylation refers to the process of linking to the original surfactant by polymerizing ethylene oxide. After this process, the performance as a surfactant will become great. Furthermore, the number following polyethylene glycol (PEG) can be regarded as the number of ethylene oxide polymerized with the original component. For example, in "Polyethylene Glycol-60 Hydrogenated Castor Oil", 60 ethylene oxides are linked throug...

Claims

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Application Information

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IPC IPC(8): A61K8/39A61K8/46A61K8/34C09K23/00
CPCA61K8/345A61K8/39A61K8/466A61K2800/49A61K2800/10A61K2800/30A61Q19/00A61Q13/00C09K23/017
Inventor 李忠根
Owner 李忠根
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