Method for preparing amide compounds through oxidation of amine under catalysis of manganese oxide

Abstract

The invention relates to a method for preparing amide compounds through oxidation of amine under the catalysis of manganese oxide, belonging to the field of catalysts used for synthesis of amide compounds. The method comprises the following steps: adding an organic solvent, an organic amine substrate and a catalyst into a pressure vessel and carrying out uniform mixing; then introducing oxygen; and forming C=O double bonds on alpha carbon of the organic amine substrate through the catalytic oxidation of the catalyst in the process of a reaction, then preparing amido groups and eventually producing amide compounds. The catalyst used in the invention is cheap and easily available; the active component of the catalyst is manganese oxide, and no precious metal is used, so the preparation costof the catalyst is low, which is beneficial for large-scale production of the catalyst. The method is low in reaction temperature and does not need extra reaction aids in the process of synthesis, nopoisonous and harmful by-product is produced after the reaction, and the whole synthesis process is green and environment-friendly.

Description

technical field [0001] The invention relates to a catalyst for synthesizing amide compounds, in particular to a method for preparing amide compounds by catalyzing amine oxidation with manganese oxide. Background technique [0002] As an important class of chemical products, amides have high economic value and application value, and are widely used in daily life, industrial production and medical and health fields (for example, amides are widely used in organic synthesis reactions as intermediates, as a Raw materials can be used to synthesize plastics, paints, detergents, lubricants, etc.). The synthetic method of traditional amide comprises: (1) carry out condensation acylation reaction to carboxylic acid and its derivative (such as acid chloride, acid anhydride, ester) and amines (comprising ammoniacal liquor) to obtain amide; (2) carry out acidification to ketoxime Catalyzed rearrangement yields amides and the like. However, the synthesis of amides by these traditional m...

AI Technical Summary

Problems solved by technology

However, this method has disadvantages such as high cost and high energy consumption.