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A kind of alpha-linolenic acid ethyl ester microemulsion and preparation method thereof

A technology of ethyl linolenate and microemulsion, which is applied in the field of chemistry, can solve the problems of unsuitable α-ethyl linolenate microemulsion, etc., and achieve the effects of large-scale production, good stability, and expanded use scenarios

Inactive Publication Date: 2019-11-15
ANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the selection and compatibility of components in these microemulsions are not suitable for α-ethyl linolenic acid microemulsions. Seeking to develop α-ethyl linolenic acid microemulsions is an effective way to expand its application

Method used

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  • A kind of alpha-linolenic acid ethyl ester microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] At 25°C, Tween80: salicylic acid=10:1 by mass ratio to form a mixed surfactant 33.6g, 0.084g vitamin E, 8.4g ethylated perilla oil and mixed surfactant were mixed under slow stirring Mix well, then slowly add 58g of water to the mixing system until the mixed solution turns from turbid to clear and transparent liquid, then continue to add water to the required quality (the purpose is to adjust the concentration, and the amount of water added should be determined according to the final concentration) , at this time, it is still a clear and transparent liquid.

[0016] In this example, an oil-in-water microemulsion with a clear and transparent appearance of nano-scale ethyl linolenate was prepared. Further, the particle size of the nano-scale microemulsion of this embodiment was measured using a dynamic light-scattering instrument, and the average particle radius was 14.407nm, and its stability analysis was carried out: the microemulsion was centrifuged at 3000r / min for 30...

Embodiment 2

[0018] At 25°C, Tween80: salicylic acid=10:1 by mass ratio to form a mixed surfactant 3.5g, 0.057g vitamin E, 5.7g ethylated perilla oil and the mixed surfactant were mixed under slow stirring Mix it evenly, then slowly add 0.7g of water to the mixing system until the solution changes from turbid to clear and transparent liquid, then carefully add water to the required mass (the purpose is to adjust the concentration, the final concentration needs to determine the water content) Added amount), at this time, it is still a clear and transparent liquid.

[0019] In this example, a water-in-oil microemulsion with a clear and transparent appearance of nano-scale α-ethyl linolenate was prepared. Further, the stable analysis of the α-linolenic acid ethyl ester nano-scale microemulsion product of this implementation is carried out: the microemulsion is placed in a high-speed centrifuge at 3000r / min for 30 minutes and no phase separation occurs, or the liquid is taken out and placed in...

Embodiment 3

[0021] At 25°C, Tween80: salicylic acid = 10:1 by mass ratio to form a mixed surfactant 4.5g, 0.049g ascorbic acid, 4.9g ethylated perilla oil and the mixed surfactant were made under slow stirring Mix well, then slowly add 0.6g of water to the mixing system until the solution changes from turbid to clear and transparent liquid, then carefully add water to the required mass (the purpose is to adjust the concentration, the amount of water added should be determined according to the final concentration) , at this time, it is still a clear and transparent liquid.

[0022] In this example, a water-in-oil microemulsion with a clear and transparent appearance of nano-scale α-ethyl linolenate was prepared. Further, the stable analysis of the α-linolenic acid ethyl ester nano-scale microemulsion product of this implementation is carried out: the microemulsion is placed in a high-speed centrifuge at 3000r / min for 30 minutes and no phase separation occurs, or the liquid is taken out and...

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Abstract

Disclosed is an alpha-ethyl linolenate microemulsion. The alpha-ethyl linolenate microemulsion is prepared from, by weight, 4-70 parts of alpha-ethyl linolenate or oil phase containing alpha-ethyl linolenate, 6-40 parts of surfactant and co-surfactant, 0-1.5 parts of inorganic salt, 0.1-1.5 parts of antioxidant and the balance water. A preparation method of the alpha-ethyl linolenate microemulsioncomprises the steps of A, accurately weighing all the required components; B, controlling the heating temperature within the range of 20-30 DEG C, mixing alpha-ethyl linolenate or the oil phase containing alpha-ethyl linolenate with the antioxidant to form a mixed oil phase, and adding the surfactant and the co-surfactant to the mixture; C, adding water or water dissolved with inorganic salt intothe mixed system obtained in step B. By means of the method, alpha-linolenic acid in the microemulsion is protected and fully utilized.

Description

technical field [0001] The invention relates to α-ethyl linolenate microemulsion, in particular to an α-ethyl linolenate microemulsion and a preparation method thereof, belonging to the field of chemistry. Background technique [0002] α-Linolenic Acid (ALA for short), scientific name: all-cis-9,12,15-octadecatrienoic acid, is a high-level polyunsaturated fatty acid, which is an important component of brain cells and retina It is also the parent of omega-3 unsaturated fatty acids, which can be metabolized to produce essential eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid ( DHA) three major nutritional factors. Therefore, α-linolenic acid is an indispensable nutrient element in human health and belongs to essential fatty acids. However, it cannot be converted and synthesized in the human body, and must be supplemented through food intake. Supplement this nutrient component every day. It plays a very important role in human health. [0003] S...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/26A61K47/12A61K47/02A61K47/22A61K31/232A61K36/535A61K36/55A61P3/06A61P9/12A61P37/08A61P7/02A61P27/02A61P29/00A61P25/00A61P25/28
CPCA61K9/1075A61K31/232A61K36/535A61K36/55A61K47/02A61K47/12A61K47/22A61K47/26A61P3/06A61P7/02A61P9/12A61P25/00A61P25/28A61P27/02A61P29/00A61P37/08
Inventor 郑永军牛永生郑勇侯绍刚贾志强
Owner ANYANG INST OF TECH
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