Tea seed meal used as squalene synthetase inhibitor and application of tea seed meal in reduction of lipid

Abstract

The invention discloses tea seed meal used as a squalene synthetase inhibitor and application of the tea seed meal in reduction of lipid. It is found that the tea seed meal made of small fruits of camellia is an effectively inhibitor for a squalene synthetase. The squalene synthetase is an important enzyme for synthesis and metabolism of cholesterol and can catalyze two molecules of farnesyl diphosphate to produce squalene diphosphate serving as an intermediate under the action of reductive dimerization. Under the action of NADPH reduction, squalene diphosphate produces squalene, and squaleneis further synthesized into cholesterol. The cholesterol level can be lowered by inhibiting the activity of the squalene synthetase. Moreover, it is reported that the squalene synthetase inhibitor canlower not only the cholesterol level but also the triglyceride level, so that a lipid lowering effect is achieved. Therefore, the tea seed meal made of small fruits of camellia can achieve the lipidlowering effect by inhibiting the squalene synthetase and can be prepared into food, medicine or health care products for lowering lipid.

Description

technical field [0001] The invention relates to the use of tea dregs of Camellia oleifera as squalene synthase inhibitor and lipid-lowering. Background technique [0002] Small fruit oil tea (Camellia meiocarpa Hu.) is also known as Jiangxizi, small tea, chicken heart, small leaf camellia, sheep excrement and so on. The fruit is small, the leaves are small, the buds are small, and the buds and bracts are not hairy. Camellia oleifera is shade-tolerant, has small fruit, thin skin, and high yield. Its cultivation area and annual output are second only to ordinary camellia oleifera. It is distributed in Fujian, Jiangxi, Guangxi, Hunan, Guizhou, Jiangsu and Zhejiang provinces. [0003] The chemical components contained in Camellia oleifera mainly include saponins, flavonoids, polyphenols, polysaccharides and protein compounds. Pharmacological studies have shown that Camellia oleifera plants not only have antibacterial, anti-inflammatory, heat-clearing and detoxifying effects, b...

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Problems solved by technology

Pharmacological studies have shown that Camellia oleifera plants not only have antibacterial, anti-inflammatory, heat-clearing and detoxifying effects, but also have good biological activities in terms of anti-oxidation and anti-tumor. Among them, camellia oleifera saponins have significant pharmacological activity on cardiovascular and cerebrovascular, but small fruit There are few reports on camellia oleifera and related pharmacological activities

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