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Compound sulfamonomethoxine sodium micro-capsule preparation and preparation method thereof

A technology of sodium methotrexate and compound sulfonamide, which is applied in the field of preparation of animal medicines, can solve the problems of poor sterilization and parasite elimination, low penetrating power, and damage to the kidneys, so as to improve penetrating power, prevent Effects of controlling toxoplasmosis and reducing damage

Inactive Publication Date: 2018-09-14
合肥中龙神力动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of compound sulfamethoxine sodium microcapsule preparation and preparation method thereof, it solves the low penetrating power of traditional sulfamethoxine sodium medicine, poor effect of sterilization and killing parasites, and defects that damage the kidneys of livestock

Method used

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  • Compound sulfamonomethoxine sodium micro-capsule preparation and preparation method thereof
  • Compound sulfamonomethoxine sodium micro-capsule preparation and preparation method thereof
  • Compound sulfamonomethoxine sodium micro-capsule preparation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0025] A compound sulfamethoxine sodium microcapsule preparation, the raw materials for making it include 8% sulfamethoxine sodium and 1% trimethoprim by mass, and the quality of the auxiliary agent is One-third of the total mass of sulfamethoxine sodium and trimethoprim is 3%, and the balance is anhydrous glucose, which is 88%.

[0026] Wherein, the auxiliary agent consists of 1 part of soluble starch, 3 parts of petroleum ether, 1 part of acetaminophen, 1 part of polyvinylpyrrolidone, 1 part of escin, 3 parts of kanamycin monosulfate, 1 part Morinda citrifolia, 1 part otilonium bromide, 1 part vernimulin, 1 part probenecid sodium, 3 parts Brucea javanica, 2 parts forsythia, 3 parts purslane, 1 part aurantium and 1 part Psoralea composition.

Embodiment 2

[0028] A compound sulfamethoxine sodium microcapsule preparation, the raw materials for making it include sulfamethoxine sodium with a mass proportion of 10% and trimethoprim with a mass proportion of 2%, and the quality of the auxiliary agent is One-third of the total mass of sulfamethoxine sodium and trimethoprim is 4%, and the balance is anhydrous glucose, which is 84%.

[0029] Wherein, the auxiliary agent consists of 2 parts of soluble starch, 4 parts of petroleum ether, 2 parts of acetaminophen, 3 parts of polyvinylpyrrolidone, 2 parts of escin, 4 parts of kanamycin monosulfate, 2 parts of Morinda citrifolia, 2 parts of otilonium bromide, 3 parts of vernimulin, 3 parts of probenecid sodium, 4 parts of Brucea javanica, 3 parts of forsythia, 4 parts of purslane, 2 parts of aurantium and 2 parts Psoralea composition.

Embodiment 3

[0031] A compound sulfamethoxine sodium microcapsule preparation, the raw materials for making it include sulfamethoxine sodium with a mass proportion of 12% and trimethoprim with a mass proportion of 3%, and the quality of the auxiliary agent is One-third of the total mass of sulfamethoxine sodium and trimethoprim is 5%, and the balance is anhydrous glucose, which is 80%.

[0032] Wherein, the auxiliary agent consists of 3 parts of soluble starch, 5 parts of petroleum ether, 4 parts of acetaminophen, 4 parts of polyvinylpyrrolidone, 3 parts of escin, 5 parts of kanamycin monosulfate, 3 parts of Morinda officinalis, 3 parts of otilonium bromide, 5 parts of vernimulin, 4 parts of probenecid sodium, 5 parts of Brucea javanica, 4 parts of forsythia, 5 parts of purslane, 4 parts of aurantium and 3 parts of Psoralea composition.

[0033] combine figure 1 Shown, above-mentioned each embodiment all adopts following method to prepare:

[0034] A preparation method of compound sulfa...

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Abstract

The invention discloses a compound sulfamonomethoxine sodium micro-capsule preparation and a preparation method thereof. The compound sulfamonomethoxine sodium micro-capsule preparation is prepared from sulfamonomethoxine with 8-12% of mass ratio, trimethoprim with 1-3% of mass ratio, the balance glucosum anhydricum and the balance addition agent. The preparation has the advantages that the cooperative use of 10% of sulfamonomethoxine, 2% of trimethoprim micro-capsule and addition agent is adopted, the preparation penetrating power is effectively improved, and toxoplasma cysts can be penetrated, and toxoplasmosis can be effectively prevented and controlled. Damage to the pig kidney is relieved through a micro-capsule technology, and the preparation is specially applied to the use of pregnant sows.

Description

technical field [0001] The invention relates to the technical field of preparation of animal medicines, in particular to a compound sulfamethoxine sodium microcapsule preparation and a preparation method thereof. Background technique [0002] Animal parasitic diseases are an important part of livestock infectious diseases that cannot be ignored, and there are many types of pathogenic parasites. Common internal parasites include roundworms, flagellates, strongyloids, trichinella, nodularia, coccidia, tapeworms, trematodes Etc. External parasites include ticks, fleas, flies, ticks, lice, etc. It seriously affects the output of meat, milk and eggs, the quality of fur, seriously restricts the healthy development of animal husbandry, and some zoonotic parasitic diseases also directly endanger human health, causing huge economic losses to the animal husbandry industry and causing serious public health problem. [0003] Sodium sulfamonomethoxine is the sulfa drug with the stronge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/32A61K47/08A61K31/635A61K31/505A61K36/752A61P33/00A61P33/10A61P33/12A61P33/14A61P33/02A61K31/167A61K31/366A61K31/7036A61K31/245A61K31/22A61K31/195
CPCA61K9/501A61K9/5026A61K31/167A61K31/195A61K31/22A61K31/245A61K31/366A61K31/505A61K31/635A61K31/7036A61K36/185A61K36/487A61K36/634A61K36/746A61K36/752A61K47/08A61K47/32A61K47/36A61P33/00A61P33/02A61P33/10A61P33/12A61P33/14A61K2300/00
Inventor 乐其新詹松鹤吴昊明文庆史洋洋孟晨
Owner 合肥中龙神力动物药业有限公司
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