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Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on metabonomics and research method

A technology of anti-diabetes and metabolomics, applied in the field of medicine

Active Publication Date: 2018-09-07
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology

[0008] The purpose of the present invention is to provide a metabolomics-based metabolic pathway and research method of Yaoshan sweet tea’s anti-diabetic potential markers, aiming at the difficulty that the existing pharmacological methods cannot completely and comprehensively explain the anti-diabetic mechanism of Guangxi Yaoshan sweet tea. Provide a basis for the further development and utilization of Yaoshan sweet tea

Method used

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  • Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on metabonomics and research method

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Embodiment Construction

[0044] A clear and complete description is given below in conjunction with the technical solutions in the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative efforts belong to the protection scope of the present invention.

[0045] The concrete realization process of the inventive method is as follows:

[0046] A metabolomics-based metabolic pathway and research method for anti-diabetic potential markers of Guangxi Yaoshan sweet tea, using nuclear magnetic resonance technology to detect and analyze urinary metabolites in streptozotocin-induced diabetic rats and Yaoshan sweet tea intervention, obtained Metabolic fingerprinting. Nine potential anti-diabetic urine markers of Yaoshan sweet tea were screened and identified by multivariate statistical analysis, and the anti-diabetic metabolic pathway of Yaoshan sweet tea was screened out; six anti-diabetic metabol...

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Abstract

The invention discloses a Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on the metabonomics and a research method, which relates to a research method for a natural plant medicine action mechanism. The invention aims at solving the problems that the existing single pharmacology method cannot systematically and comprehensively evaluate the action mechanism of the natural plant medicine. The method comprises the following steps: (1) detecting and analyzing a urine metabolite of a diabetic rat after being induced by streptozotocin and intervened by rubus suavissimus; (2) selecting nine rubus suavissimus antidiabetic related urine potential markers, and identifying the potential markers; and (3) selecting six metabolic pathways of the rubus suavissimus for resisting the diabetics, and analyzing. By adopting the Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway and the research method, the antidiabetic action mechanism of the rubus suavissimus can be more comprehensively, efficiently, rapidly and integrally evaluated without deviation, and evidence can be provided for the description and further development of the national medicine action mechanism.

Description

technical field [0001] The invention belongs to the field of medicine. Specifically, it is a metabolic pathway and research method of potential anti-diabetic markers of Guangxi Yaoshan sweet tea based on metabolomics. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia, and has become the third major chronic disease that seriously endangers human health. The resulting cardiovascular and microvascular complications have become the main cause of death and disability. There is a cure. IDF estimates that the number of people with type 2 diabetes in my country will reach 143 million in 2035, and 50.1% of adults will be pre-diabetic. A huge economic burden on families and society. Therefore, it is of great significance and urgency to find drugs that can prevent and intervene in the pathogenesis of type 2 diabetes and to clarify its mechanism of action for improving the health of our people. [0003] For a long time, medical res...

Claims

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Application Information

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IPC IPC(8): G01N24/08
CPCG01N24/088
Inventor 郑华夏宁梁瑜祯刘旭文苏志恒孟春梅李卫东魏秋梅何丽丽
Owner GUANGXI MEDICAL UNIVERSITY
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