Slow release type chitosan antibacterial dressing and preparation method thereof

A chitosan and slow-release technology, which is applied in the field of slow-release chitosan antibacterial dressings and its preparation, can solve the problems of inability to meet wound healing requirements and poor functionality, and achieve prolonged effective action time and cell compatibility Good, Wide Variety of Effects

Pending Publication Date: 2018-09-07
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the poor functionality of traditional dressings, the problem of being unable to meet the requirements of wound healing, the object of the present inventi

Method used

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  • Slow release type chitosan antibacterial dressing and preparation method thereof
  • Slow release type chitosan antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of preparation method of slow-release chitosan antibacterial dressing, concrete steps are as follows:

[0040] S1. Shell layer preparation: dissolve chitosan powder in acetic acid aqueous solution, dissolve polyvinyl alcohol powder in distilled water, stir and dissolve with a magnetic stirring device; mix chitosan acetic acid aqueous solution and polyvinyl alcohol solution in a mass ratio of 1:1-1 : 2 ratio mixing, the mixed solution is placed in a constant temperature oscillator at 70°C and magnetically stirred evenly, and the shell solution is obtained after standing still for defoaming;

[0041] S2. Core layer preparation: using human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) as solutes, and phosphate buffer solution with pH=7.2 as solvent to prepare a core layer solution;

[0042] The bovine serum albumin (BSA) is a stabilizer, and the concentrations of human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) are 20 mg / L and 0...

Embodiment 2

[0048] A kind of preparation method of slow-release chitosan antibacterial dressing, concrete steps are as follows:

[0049] S1. Shell layer preparation: dissolve chitosan powder in acetic acid aqueous solution, dissolve polyvinyl alcohol powder in distilled water, stir and dissolve with a magnetic stirring device; mix chitosan acetic acid aqueous solution and polyvinyl alcohol solution in a mass ratio of 1:1-1 : 2 ratio mixing, the mixed solution is placed in a constant temperature oscillator at 70°C and magnetically stirred evenly, and the shell solution is obtained after standing still for defoaming;

[0050] S2. Core layer preparation: using human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) as solutes, and phosphate buffer solution with pH=7.2 as solvent to prepare a core layer solution;

[0051] The bovine serum albumin (BSA) is a stabilizer, and the concentrations of human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) are 20 mg / L and 0...

Embodiment 3

[0057] A kind of preparation method of slow-release chitosan antibacterial dressing, concrete steps are as follows:

[0058] S1. Shell layer preparation: dissolve chitosan powder in acetic acid aqueous solution, dissolve polyvinyl alcohol powder in distilled water, stir and dissolve with a magnetic stirring device; mix chitosan acetic acid aqueous solution and polyvinyl alcohol solution in a mass ratio of 1:1-1 : 2 ratio mixing, the mixed solution is placed in a constant temperature oscillator at 70°C and magnetically stirred evenly, and the shell solution is obtained after standing still for defoaming;

[0059] S2. Core layer preparation: using human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) as solutes, and phosphate buffer solution with pH=7.2 as solvent to prepare a core layer solution;

[0060] The bovine serum albumin (BSA) is a stabilizer, and the concentrations of human epidermal growth factor (rhEGF) and bovine serum albumin (BSA) are 20 mg / L and 0...

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Abstract

The invention discloses a slow release type chitosan antibacterial dressing and belongs to the technical field of wound repair. The problems are solved that traditional dressings have low functionality and requirements of wound healing cannot be met. The dressing comprises a nanofiber membrane and a spunlaced non-manufactured substrate; the nanofiber membrane is composed of nanofibers having a structure of a shell layer and a core layer; the core layer is made of human epidermal growth factors and bovine serum albumin, and the shell layer is made of chitosan and polyvinyl alcohol. The invention also discloses a preparation method of the slow release type chitosan antibacterial dressing. On the basis of a coaxial electrospinning technology, by combining with on on-line deposition process, the slow release type chitosan antibacterial dressing made of the human epidermal growth factors is prepared; through slow release of the human epidermal growth factors, the effective action time of the human epidermal growth factors on partial wounds is prolonged, the synergistic healing and antibacterial effects of the human epidermal growth factors and chitosan can also be exerted, and the effect of accelerating wound healing is achieved.

Description

technical field [0001] The invention belongs to the technical field of wound repair, and in particular relates to a slow-release chitosan antibacterial dressing and a preparation method thereof. Background technique [0002] Wound healing is a complex and orderly physiological process. Different healing stages have different functional requirements for wound dressings. Traditional dressings only have simple wound protection functions and cannot meet the complex requirements of wound healing. The development of composite multifunctional medical Dressings have become a top priority. Wound healing is related to many factors. Among them, wound infection is the primary factor hindering wound healing. Open wounds lose their barrier ability to defend against bacteria due to damage to skin integrity, which can easily cause local infections and even systemic infections. Therefore, the development of multifunctional medical dressings with antibacterial and healing-promoting effects ha...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/46A61L15/28A61L15/32D01D5/00
CPCA61L15/28A61L15/32A61L15/44A61L15/46D01D5/0015A61L2300/252A61L2300/602A61L2300/414C08L5/08
Inventor 付译鋆李珂常志博安琪倪瑞燕杨立双张伟李素英张瑜
Owner NANTONG UNIVERSITY
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