Traditional Chinese medicine preparation for external use for treating stroke and preparation method thereof

A traditional Chinese medicine preparation and preparation technology, which is applied in the field of external Chinese medicine preparation and its preparation for the treatment of stroke, can solve the problems of difficulty in obtaining satisfactory therapeutic effect and low cumulative percutaneous penetration, and achieve synergistic interaction of drug effects, improve mental state, The effect of improving cerebral circulation

Inactive Publication Date: 2018-09-07
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, it is difficult for ordinary transdermal drug delivery preparations to enter the cavity or lesion through the skin, and it is difficult to obtain a satisfactory therapeutic effect, and there is a bottleneck of low cumulative percutaneous penetration. The external dosage forms of traditional Chinese medicine have become a focus of current research in this field

Method used

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  • Traditional Chinese medicine preparation for external use for treating stroke and preparation method thereof
  • Traditional Chinese medicine preparation for external use for treating stroke and preparation method thereof
  • Traditional Chinese medicine preparation for external use for treating stroke and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1. An external Chinese medicinal preparation for the treatment of apoplexy, made of the following raw materials in parts by weight: 55 parts of Angelica sinensis, 45 parts of Astragalus membranaceus, 12 parts of Inula inulae, 12 parts of white mustard seed, 12 parts of fried mulberry branches, 10 parts of Duhuo, 25 parts of pine needles, 8 parts of Chuanxiong, 3 parts of licorice, 3 parts of borneol.

[0059] The preparation method comprises the steps of:

[0060] (1) Extract preparation

[0061] Except for borneol, the remaining components were ground into fine powder, added 5 times the amount of 75% ethanol phosphate solution (pH 9-11), heated and refluxed for 2 extractions for 3 hours each time, combined the extracts, and filtered. The filtrate was left to stand for 24 hours, the supernatant was taken to concentrate, the concentrates were combined, and vacuum-dried under reduced pressure to obtain a dry extract; add borneol that had been pulverized into s...

Embodiment 2

[0065] Embodiment 2. An external Chinese medicine preparation for the treatment of apoplexy, made of the following raw materials in parts by weight: 50 parts of Angelica sinensis, 50 parts of Astragalus membranaceus, 15 parts of Inula inulae, 10 parts of white mustard seed, 15 parts of fried mulberry branches, 6 parts of Duhuo, 20 parts of pine needles, 10 parts of Chuanxiong, 5 parts of licorice, and 2 parts of borneol.

[0066] The preparation method comprises the steps of:

[0067] (1) Extract preparation

[0068] Except for borneol, the rest of the components were ground into fine powder, added 6 times the amount of 80% ethanol phosphate solution (pH 9-11), heated and refluxed twice for 3 hours each time, combined the extracts and filtered. The filtrate was left to stand for 24 hours, the supernatant was taken to concentrate, the concentrates were combined, and vacuum-dried under reduced pressure to obtain a dry extract; add borneol that had been pulverized into superfine...

Embodiment 3

[0072] Embodiment 3. An external Chinese medicine preparation for the treatment of apoplexy, made of the following raw materials in parts by weight: 60 parts of Angelica sinensis, 40 parts of Astragalus membranaceus, 10 parts of Inula inulae, 15 parts of white mustard seed, 10 parts of fried mulberry branches, 12 parts of lovage, 30 parts of pine needles, 5 parts of Chuanxiong, 2 parts of licorice, 5 parts of borneol.

[0073] The preparation method comprises the steps of:

[0074] (1) Extract preparation

[0075] Except for borneol, the remaining components were ground into fine powder, added 5 times the amount of 85% ethanol phosphate solution (pH 9-11), heated and refluxed for 2 extractions for 3 hours each time, combined the extracts, and filtered. The filtrate was left to stand for 24 hours, the supernatant was taken to concentrate, the concentrates were combined, and vacuum-dried under reduced pressure to obtain a dry extract; add borneol that had been pulverized into s...

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Abstract

The invention provides a traditional Chinese medicine preparation for external use for treating stroke and a preparation method thereof. The components of the traditional Chinese medicine are reasonable, synergy and interaction of various medicine effects are achieved, and the effects are significant. Qi-tonifying drug and blood-activating drug are matched to make qi vigorous, promote blood circulation and invigorate the blood circulation, and human bodies cannot be affected; phlegm reduction and brain strengthening drug is added and has an assistant effect to reinforce qi and nourish blood, warm and activate meridian, and eliminate phlegm and strengthen brain. The effects of promoting qi circulation, invigorating the blood circulation, eliminating phlegm, promoting blood circulation, andtreating stroke are achieved. According to the traditional Chinese medicine preparation, a hydrogel dosage form for external use is preferred, medicine efficacy can directly treat the illness position, the situations that after oral administration, milder medicine efficacy may cause endogenous heat evil and tepidity and yin impairment can be avoided, the use is convenient, peroral misery is avoided, and the traditional Chinese medicine preparation is particularly applicable to paralytic patients. According to the traditional Chinese medicine preparation, the transdermal absorption is achieved,continuous administration is performed, the transdermal release and adsorption are good, and significant effects of treating stroke symptoms such as facial paralysis, drooling, stiff tongue and speaking difficulty, numb muscles, arthralgia and myalgia and the like which are caused by wind-evil and collateral stroke are achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an external Chinese medicinal preparation for treating stroke and a preparation method thereof. Background technique [0002] Stroke, also known as cerebral apoplexy, apoplexy, etc., is mostly caused by qi and blood inversion, cerebral paralysis, or blood overflowing in the brain. Sudden hemiplegia without fainting is a kind of disease whose main symptom is. Stroke is currently the third leading cause of death after cardiovascular disease and tumors. Stroke has the characteristics of high morbidity, high mortality, high disability rate, and many complications, which seriously threaten human health. Among them, the incidence rate of ischemic stroke is high. [0003] Ischemic stroke is the damage of brain tissue caused by the reduction of blood flow, and the subsequent changes in neurological function. In the field of traditional Chinese medicine, most mode...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61K9/70A61P9/10A61K31/045
CPCA61K36/232A61K9/7023A61K31/045A61K36/15A61K36/236A61K36/28A61K36/31A61K36/481A61K36/484A61K36/605A61K47/32A61K2236/333A61K2236/39A61K2236/51A61P9/10A61K2300/00
Inventor 吴世德郭之梁王诗青王红霞马双胡安平郑莲贾美春王春付立青陈露露
Owner SHANDONG MINGREN FURUIDA PHARMA
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