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Use of dihydroisoquinolinium double derivatives for treating keratin materials, compositions and implementation processes

A technology of keratin fibers and uses, applied in the field of human keratin fibers such as hair, medium compositions, compositions for treating keratin materials, and compositions for brightening keratin materials, which can solve problems such as skin irritation and achieve brightening improvement Effect

Active Publication Date: 2018-08-21
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, this combination often causes degradation of keratinous materials, especially keratinous fibers, and may possibly lead to varying degrees of skin irritation

Method used

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  • Use of dihydroisoquinolinium double derivatives for treating keratin materials, compositions and implementation processes
  • Use of dihydroisoquinolinium double derivatives for treating keratin materials, compositions and implementation processes
  • Use of dihydroisoquinolinium double derivatives for treating keratin materials, compositions and implementation processes

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0159] ●R 1 and R' 1 same as each other, R 2 and R' 2 same as each other, R 3 and R' 3 same as each other, R 5 and R' 5 same as each other, R 6 and R' 6 same as each other, R 7 and R' 7 same as each other, R 8 and R' 8 same as each other, R 9 and R' 9 same as each other, R 10 and R' 10 are identical to each other, and each pair independently represents a group selected from the following:

[0160] -A hydrogen atom;

[0161] - a halogen atom,

[0162] - C optionally substituted by one or more groups 1 -C 6 Alkyl, the one or more groups may be the same or different, selected from hydroxyl, cyano, C 1 -C 6 Alkoxy and amino NR a R b group,

[0163] -C 1 -C 6 alkoxy;

[0164] - Hydroxy;

[0165] - Amino NR a R b ,

[0166] -Aminocarbonyl –CONH 2 ,

[0167] -Carboxyl –CO 2 H,

[0168] ●R 4 and R' 4 together form a divalent group L such that L represents a linear or branched, saturated or unsaturated C 1 -C 15 Alkylene, optionally substituted by...

no. 2 approach

[0192] ●R 1 and R' 1 same as each other, R 2 and R' 2 same as each other, R 5 and R' 5 same as each other, R 6 and R' 6 same as each other, R 7 and R' 7 same as each other, R 8 and R' 8 same as each other, R 9 and R' 9 same as each other, R 10 and R' 10 are identical to each other, and each pair independently represents a group selected from the group consisting of:

[0193] -A hydrogen atom;

[0194] - a halogen atom,

[0195] - C optionally substituted by one or more groups 1 -C 6 Alkyl, the one or more groups may be the same or different, selected from hydroxyl, cyano, C 1 -C 6 Alkoxy and amino NR a R b group,

[0196] -C 1 -C 6 alkoxy;

[0197] - Hydroxy;

[0198] - Amino NR a R b ,

[0199] -Aminocarbonyl –CONH 2 ,

[0200] -Carboxyl –CO 2 H,

[0201] ●R 4 and R' 4 are the same and represent C optionally substituted with one or more groups 1 -C 6 Alkyl, the one or more groups may be the same or different, selected from hydroxyl, C 1 -...

Embodiment 1

[0392] Synthesis of 2,2'-butane-1,4-diyldi-3,4-dihydroisoquinolinium dibromide (compound 1)

[0393]

[0394] 10 g of 3,4-dihydroisoquinoline (4 equivalents) was placed in 75 mL of toluene in a 250 mL three-necked flask, followed by the addition of 2.28 mL of 1,4-dibromobutane (1 equivalent). The mixture was refluxed for 15 hours with vigorous stirring. The beige-brown precipitate was filtered off under vacuum and under argon, washed with diisopropyl ether, and then washed with P 2 o 5 dry.

[0395] The product was recrystallized from 80 mL of n-propanol and isolated as a beige colored powder (5.15 g, yield = 56.5%).

[0396] Analysis is based on expected product.

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PUM

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Abstract

The present invention relates to the use of one or more dihydroisoquinolinium double salts for treating keratin materials, in particular keratin fibres, especially human keratin fibres such as the hair. The invention also relates to a process for treating keratin materials using said salts and optionally in the presence of one or more chemical oxidizing agents. A subject of the invention is also acomposition for lightening keratin materials, comprising one or more dihydroisoquinolinium double salts as defined below and one or more chemical oxidizing agents. The present invention also relatesto one or more particular dihydroisoquinolinium double salts and also to compositions containing them, in particular compositions comprising a physiologically acceptable medium.

Description

technical field [0001] The present invention relates to the use of one or more dihydroisoquinolinium double salts for the treatment of keratinous materials, especially keratinous fibers and skin, especially human keratinous fibers such as hair. The invention also relates to a method for treating keratinous material using said salt, optionally in the presence of one or more chemical oxidizing agents. [0002] A subject of the present invention is also a composition for lightening keratin materials, comprising one or more dihydroisoquinolinium double salts as defined below and one or more chemical oxidizing agents. [0003] The present invention also relates to one or more specific dihydroisoquinolinium double salts and also to compositions containing them, especially compositions comprising a physiologically acceptable medium. Background technique [0004] Hair lightening or bleaching is often necessary when a person wishes to change the color of her hair, especially when sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/06
CPCA61K8/4926A61K8/22A61K8/49A61Q5/08C07D217/10C07D217/14A61Q5/10C07D401/06A61Q5/065A61K2800/4322A61K8/38
Inventor 斯特凡纳·萨贝尔阿齐兹·法德利
Owner LOREAL SA
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