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Tissue engineering artificial liver-like tissue construction mold and method for manufacturing the injection mold of the mold

A tissue engineering and injection mold technology, applied in the field of bionics, can solve problems such as insufficient bionic degree of liver lobules, and achieve the effects of improving inoculation effect, improving function and activity, and increasing capacity

Active Publication Date: 2020-06-02
GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some scholars have carried out disordered stacking of cell aggregates to achieve three-dimensional high-density culture, and the degree of scale is also high, but the degree of bionicity at the level of liver lobules is still insufficient

Method used

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  • Tissue engineering artificial liver-like tissue construction mold and method for manufacturing the injection mold of the mold
  • Tissue engineering artificial liver-like tissue construction mold and method for manufacturing the injection mold of the mold
  • Tissue engineering artificial liver-like tissue construction mold and method for manufacturing the injection mold of the mold

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Embodiment Construction

[0069] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0070] The inventors of the present invention studied the microstructure of the liver and found that its composition structure is progressive layer by layer. The hepatic cord is formed by the linear connection of liver cells. , The hepatic lobules are distributed in a hexagonal array to form the liver. The regular hexagon is the structural feature of the liver lobules, about 1*1*2mm 3 Size, the center is the central venule, and the periphery is the portal area. The veins in the center of the hepatic lobule and the surrounding portal ar...

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Abstract

The invention provides a tissue engineering artificial liver-like tissue construction mold and a method for manufacturing the tissue engineering artificial liver-like tissue construction mold. The tissue engineering artificial liver-like tissue construction mold comprises a mold main body, a first height-increasing body and a second height-increasing body, wherein the first height-increasing bodyand the second height-increasing body are matched with the mold main body, the first height-increasing body is placed on the mold main body and is used for increasing the capacity of the mold main body so as to inoculate micro liver cells, and the second height-increasing body is used for fixing a dialysis membrane and separating a cell sodium alginate suspension from an upper layer calcium chloride solution, wherein the calcium chloride solution is added to the upper layer of the dialysis membrane, and the calcium ions can penetrate through the dialysis membrane so as to achieve the gelatinous sodium alginate. Compared to the mold in the prior art, the tissue engineering artificial liver-like tissue construction mold of the present invention has the following characteristic that the aggregated cells are re-assembled by the tissue engineering artificial liver-like tissue construction mold to make the aggregated cells be distributed and arranged in a hepatic lobule imitating hexagon manner, such that the gaps similar to the portal area, the central vein and the liver sinusoid are formed between the micro liver cells so as to easily achieve the in vivo vascularization process and improve the efficacy of the liver cells per unit volume, and so as not to affect the substance exchange efficiency.

Description

technical field [0001] The invention relates to the field of bionic technology, in particular, the invention relates to a tissue engineering artificial liver-like tissue construction mold and a method for manufacturing the injection mold of the mold. Background technique [0002] Tissue engineering is a new interdisciplinary discipline developed in the late 1980s. In recent years, with the development of life science, material science and engineering science, researchers have successively made breakthroughs in the research of in vitro reconstruction of various tissues and organs. Among them, some tissue engineering products such as cartilage and skin have been commercialized. Liver tissue engineering is one of the important research directions in the field of tissue engineering research. Its goal is to construct a transplantable liver tissue or organoid to treat patients with impaired liver function. Today, scientists have simulated the natural liver in the body and success...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C33/38B29C45/26
CPCB29C33/3842B29C45/26
Inventor 高毅张斌斌彭青李海燕
Owner GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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