Monosubstituted cobaltocene cationic derivative and high-efficiency preparation method

A cobaltocene and single-substitution technology, which is applied in chemical instruments and methods, metallocenes, organic chemistry, etc., can solve the problems of few reports on cobaltocene derivatives, achieve simple and fast post-treatment, high reaction efficiency, Simple and easy to operate effect

Inactive Publication Date: 2018-08-10
NORTHWESTERN POLYTECHNICAL UNIV
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to synthetic challenges, monosubstituted cobaltocene derivatives have rarely been reported
In particular, there are almost no reports on cobaltocene derivatives substituted by various functional groups.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Monosubstituted cobaltocene cationic derivative and high-efficiency preparation method
  • Monosubstituted cobaltocene cationic derivative and high-efficiency preparation method
  • Monosubstituted cobaltocene cationic derivative and high-efficiency preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation method of two kinds of compounds represented by general formula I, according to figure 1 The compound reacts according to the specified route to obtain one of the following general formulas:

[0039]

[0040] In the reaction, R=-C 12 h 25 ,-C 14 h 29 ,-C 16 h 33 ,-(CH 2 ) 11 OOC (C 5 h 5 ) 2 Fe,-(CH 2 ) 2 OH; R'=-CH 2 C(CH 2 Oh) 2 CH 2 -, -C 12 h 24 -, TMS means trimethylsilyl.

Embodiment 1

[0041] Embodiment 1: when R=-C 12 h 25 preparation of

[0042] Dissolve 2.32 mmol of trimethylsilyl-protected alkynyl cobaltocene cobalt hexafluorophosphate and 1.06 mmol of bis-azido-neopentyl glycol in 20 mL of anhydrous acetonitrile, and deoxygenate with nitrogen for 30 min; at the same time, in another round-bottomed flask Add 0.2mmol cuprous iodide (CuI) to the solution, pass nitrogen gas to remove oxygen for 30min; then transfer the acetonitrile solution to the flask of CuI under the protection of nitrogen, add 10.6mmol finely ground anhydrous potassium carbonate after 5min, and protect it under nitrogen at 40°C Under reaction 24h. The reacted suspension was filtered, rinsed with acetonitrile, and then concentrated by rotary evaporation. The concentrated solution was added dropwise to absolute ethanol, and the precipitate was collected and dried in a vacuum oven for 24 hours to obtain 81% of compound I-1.

[0043] 1 H NMR (d 6 -DMSO, δ / ppm) 3.28 (m, 4H), 4.54 (s, 4H...

Embodiment 2

[0049] Embodiment 2, the R=-C 14 h 29 When the preparation

[0050] Dissolve 3.262 mmol of trimethylsilyl-protected alkynyl cobaltocene cobalt hexafluorophosphate and 2.965 mmol of 1-azidodecane in 20 mL of anhydrous acetonitrile, and deoxygenate with nitrogen for 30 min; at the same time, in another round-bottomed flask Add 0.6mmol cuprous iodide (CuI), pass nitrogen gas to remove oxygen for 30min; then transfer the acetonitrile solution to the flask of CuI under nitrogen protection, add 29.6mmol finely ground anhydrous potassium carbonate after 5min, at 40°C under nitrogen protection Reaction 24h. After the reaction, the suspension was filtered, rinsed with acetonitrile, and then concentrated by rotary evaporation. The concentrated solution was added dropwise to anhydrous ether, and the precipitate was collected and dried in a vacuum oven for 24 hours to obtain 80% of compound I-2.

[0051] 1 H NMR (d 6 -DMSO,δ / ppm)0.86(t,3H),1.22(m,18),1.86(t,2H),4.42(t,2H),5.67(s,5H),...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a monosubstituted obaltocene cationic derivative and a high-efficiency preparation method. The preparation process is completed in one step by a one-pot method; an expensive catalyst is not needed; the operation is simple, easy and feasible; the reaction condition is mild; the reaction efficiency is high; the column separation is not needed; the post treatment is simple, convenient and quick, and the target monosubstituted obaltocene cationic derivative can be applied to the fields of novel surfactants, novel polyelectrolyte materials, antibacterial materials and fuel-cell diaphragms, and the like.

Description

technical field [0001] The invention belongs to the field of organic synthesis, especially the technical field of organometallic chemistry, and relates to a monosubstituted cobaltocene cobalt cation derivative and a high-efficiency preparation method. Background technique [0002] Metallocene derivatives are widely used in electrochemical sensing, catalysts, biomedicine and other fields. Unlike conventional neutral ferrocenes, the most stable state of cobalt-ferrocenes is usually cobalt-ferrocene cations carrying a positive charge. However, monosubstituted cobaltocene derivatives have rarely been reported due to synthetic challenges. In particular, there are few reports on cobaltocene derivatives substituted by various functional groups. The ionic cobaltocene cation is easily adsorbed on silica gel, and its separation and purification has always been one of the difficult problems in this field. The present invention designs and synthesizes a series of derivatives containi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07F17/02
CPCC07F17/02
Inventor 闫毅颜静李学装张雪黄慧雅
Owner NORTHWESTERN POLYTECHNICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap