Production method of beta-alanine

Abstract

The invention belongs to the technical field of chemistry, and particularly relates to a production method of beta-alanine. The method comprises the following steps of leading an ammonia-water mixtureand alanine respectively into a pipeline reactor to perform continuous reaction, and then performing deamination, dehydration, alcohol precipitation and crystallization treatment on reaction productsto obtain the beta-alanine; in a normal temperature state, the ammonia-water mixture at least comprises NH4<+> and CO3<2->; the method provided by the invention is simple, safe, and high in both reaction selectivity and product yield.

Description

technical field [0001] The invention belongs to the technical field of chemistry, in particular to a production method of beta-alanine. Background technique [0002] β-alanine (β-alanine), that is, 3-aminopropanoic acid (3-aminopropanoic), is the only β-type non-protein amino acid that exists in nature. As an important biochemical raw material, β-alanine is widely used in the fields of medicine, feed and food. [0003] In the prior art, the processes for producing β-alanine by chemical synthesis mainly include the acrylonitrile method and the acrylic acid kettle method. Among them, the acrylonitrile method is obtained by high-temperature ammoniation reaction of acrylonitrile and ammonia water as raw materials. This method has the following disadvantages: one is to use nitrile-containing chemicals as raw materials, which causes serious environmental pollution; the other is β-amino Propionitrile will produce more by-products in the reaction and hydrolysis process, which is d...

AI Technical Summary

Problems solved by technology

Among them, the acrylonitrile method is obtained by high-temperature ammoniation reaction of acrylonitrile and ammonia water as raw materials. This method has the following disadvantages: one is to use nitrile-containing chemicals as raw materials, which causes serious environmental pollution; the other is β-amino During the reaction and hydrolysis of propionitrile, many by-products will be produced, which are difficult to separate from the target product and affect the conversion rate of the reaction.

In addition, the acrylic acid tank method is to react acrylic acid and ammonia water in a batch tank reactor to generate β-alanine. The main disadvantages of this method are as follows: one is that the selectivity of β-alanine is low, Usually below 50%, more by-products are produced in the reaction process, and it is difficult to separate from β-alanine. The second is that the reaction pressure required for the reaction in the batch reactor is high, and there are certain safety hazards