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Disposable bioprocess system supporting biological activity

A biological treatment and biological activity technology, applied in the direction of biomass pretreatment, method of supporting/immobilizing microorganisms, biomass post-treatment, etc.

Pending Publication Date: 2018-07-31
特定瑞士股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Downstream processing may also be performed in external facilities

Method used

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  • Disposable bioprocess system supporting biological activity
  • Disposable bioprocess system supporting biological activity
  • Disposable bioprocess system supporting biological activity

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Experimental program
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Embodiment Construction

[0080] It is an object of the present invention to provide a single-use bioprocessing system that supports biological activity, comprising: a fluid-tight container comprising a volume of process liquid medium surrounded by walls that separate the internal process liquid volume from the external facility area Separated, wherein the volume of treatment liquid is in communication with a first liquid valve and delivery liquid pumping means for pumping the treatment liquid in a direction away from the internal treatment liquid; and the volume of treatment liquid is communicated with a second liquid The valve communicates with filter means separating the internal process liquid volume from the external facility area, wherein the internal process liquid volume (12d) from said fluid-tight container (12a) to said pumping means (15) liquid communication means, another non-filtered liquid communication means extending from said pumping means (15) to a non-filtered first liquid communicati...

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Abstract

The present invention relates to a Disposable Bioprocess System consisting of a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. The system is combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet portof the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connectsvia a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.

Description

technical field [0001] The present invention relates to a disposable biological treatment system consisting of a single-use bioreactor, a single-use pumping device and a single-use microbial retention filter. Best suited for culturing suspension microorganisms in liquid media with high microbial concentration for expression of biological material and a method for operating said single-use bioprocessing system in continuous processing. Background technique [0002] In pharmaceutical bioreactors and fermenters, the goal is to grow or ferment microorganisms for the production of biomaterials or biomass for medical applications. These are medical applications such as regenerative medicine and therapeutic applications or pharmaceuticals, or the more traditional expression of living cells or molecules of microorganisms used as therapy or as medicine. [0003] Reusable non-disposable Stirred Tank Reactors (STR) as bioreactors or fermenters in sizes from less than one liter to over...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/06C12M1/12
CPCC12M23/38C12M23/40C12M27/02C12M29/00C12M29/04C12M29/10C12M29/18C12M29/26C12M37/04C12M23/28C12M47/10C12M25/02
Inventor P·施托贝
Owner 特定瑞士股份有限公司
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