Mesoporous silica matrix composite microsphere with efficient coagulation function and preparation method thereof

Abstract

The invention discloses a mesoporous silica matrix composite microsphere with an efficient coagulation function and a preparation method thereof. The mesoporous silica matrix composite microsphere comprises mesoporous silica and natural polysaccharide, and the diameter of the mesoporous silica matrix composite microsphere is 0.2-5 millimeters. A granulation solution containing the weight ratio of100:800-3000:5-200:5-50 of mesoporous silica, water, natural polysaccharide and foaming pore forming agent is dropped into a consolidation liquid to obtain the mesoporous silica matrix composite microsphere. The preparation process is simple and efficient, granulation forming and secondary pore-forming are carried out to eliminate the problems of dust, noise pollution and high energy consumption in secondary calcining during former granulation, the preparation period of products is shortened, and the utilization of equipment is improved. The composite microsphere has functions of quick coagulation, sealing and sticking wounds, reducing bleeding amount and the like, can be applied to the fields of tissue engineering, skin regeneration and the like, and has great clinical application value.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a mesoporous silicon-based composite hemostatic microsphere with rapid and efficient coagulation function and a preparation method thereof. Background technique [0002] Traumatic hemorrhage is one of the most common injuries in battlefields and various accident scenes, and uncontrolled bleeding is the primary cause of casualty death at the scene. Even if the wounded can be sent to the hospital for rescue, massive blood loss before the hospital will still cause higher mortality and serious complications (such as amputation, etc.) in the later stage. Therefore, it is of great significance to effectively control the bleeding of the wounded at the scene and before the hospital. In fact, most casualties from bleeding were preventable. The tourniquet is a life-saving device that can control bleeding, but it cannot be used or is invalid for many parts of the human body ...

AI Technical Summary

Problems solved by technology

The silica-based hemostatic agent manufactured by the traditional method only achieves the purpose of hemostasis by absorbing water and concentrating blood components. It cannot adhere well to block the bleeding site and reduce the amount of bleeding, which affects its hemostasis and tissue repair performance to a certain extent.

At the same time, the manufacturing process is complicated, the energy consumption is high, and there will be noise, dust and other pollution in the manufacturing process, which will cause certain damage to the health of manufacturing workers.

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