Online detection method of focused ultrasonic field

Abstract

The invention provides an online detection method for a focused ultrasonic field. The method comprises that ultrasonic signals are emitted and received, corresponding time delay and signal amplitude change are obtained, the sound speed and sound attenuation are calculated, a sound speed and attenuation characteristic distribution function of a biologic tissue in a treatment area can be obtained accurately in real time, and a sound field is reconstructed via a biologic layered medium model and an SBE equation. Thus, the focusing position and the sound intensity of a focus can be controlled accurately, and it is fully ensured that HIFU treatment is safe and effective.

Description

technical field [0001] The invention relates to the technical field of sound field detection, in particular to a method suitable for on-line detection of sound fields in complex biological tissues. Background technique [0002] High Intensity Focused Ultrasound (HIFU), as a new non-invasive treatment technology, has been applied to the ablation treatment of various solid tumors such as uterine fibroids, prostate cancer, liver cancer, etc., and has attracted increasing attention . Its basic principle is to focus the low-energy ultrasound emitted by the focused ultrasound transducer into the body to form a region with high energy concentration, and use the thermal mechanism and cavitation mechanism to make the diseased tissue in the region warm up to above 60°C, resulting in irreversibility. Coagulation necrosis while leaving out-of-focus normal tissue unaffected. For the biological tissue of the acoustic channel, its geometric structure and acoustic characteristics are quit...

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Problems solved by technology

[0003] However, for different biological tissues, there are individual differences in the depth of HIFU irradiation and tissue characteristics, and there are certain limitations in using the same model to describe complex biological tissues. Chinese invention patent CN 103143126 A, the patent name is "biological tissue The method of linear HIFU sound field determination” in which, aiming at the particularity of biological tissues, the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation was modified by using fractional derivatives, which proved the relationship between sound attenuation and sound velocity with frequency when sound waves propagate in biological tissues, but the Invention uses two phantom materials instead of real biological tissue

Body-like materials cannot truly reflect the specific differences in the acoustic and thermal properties of different individual tissues

When applied to clinical treatment, the geometric structure of biological tissue is often complex, with uneven distribution and specificity. According to this method, there are great limitations in calculating the sound velocity and sound attenuation to describe the acoustic properties of biological tissue, and in the process of HIFU treatment There are great difficulties in online detection of focused ultrasound sound field

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